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IL18 — VCAM1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: VCAM1 → IL18 (increases, IL18 Translocation) Morel et al., J Biol Chem 2002*
  Evidence: In an alternate pathway, inhibition of IL-1 receptor-associated kinase-1 (IRAK) with AS ODN to IRAK reduced IL-18-induced expression of nuclear factor kappaB (NFkappaB). Finally, IL-18-induced cell surface VCAM-1 expression was inhibited by treatment with AS ODNs to c-Src, IRAK, PI3-kinase, and ERK1/2

Text-mined interactions from Literome

Vidal-Vanaclocha et al., Proc Natl Acad Sci U S A 2000 (Liver Neoplasms...) : Exogenous IL-18 added to HSE also increased the number of adhering melanoma cells ; however, this was not affected by IL-1 receptor blockade or TNF neutralization but rather by anti-VCAM-1
Morel et al., J Biol Chem 2001 (Arthritis, Rheumatoid) : IL-18 significantly enhanced ICAM-1 and VCAM-1 expression on endothelial cells and RA synovial fibroblasts ... IL-18 requires NF kappa B as well as PI 3-kinase to induce VCAM-1 on RA synovial fibroblasts, suggesting that there may be two distinct pathways in IL-18 induced adhesion molecule expression
Morel et al., J Biol Chem 2002 (Arthritis, Rheumatoid...) : Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18 induced vascular cell adhesion molecule-1 expression ... Finally, IL-18 induced cell surface VCAM-1 expression was inhibited by treatment with AS ODNs to c-Src, IRAK, PI3-kinase, and ERK1/2 by 57, 43, 41, and 32 % compared with control sense ODN treatment, respectively
Faust et al., Arthritis Rheum 2002 (Autoimmune Diseases...) : IL-18 , in turn, increased apoptotic TEC death and up-regulation of intercellular adhesion molecule 1 and vascular cell adhesion molecule 1
Banning et al., Free Radic Biol Med 2004 : Inhibition of basal and interleukin-1 induced VCAM-1 expression by phospholipid hydroperoxide glutathione peroxidase and 15-lipoxygenase in rabbit aortic smooth muscle cells
Dai et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid) : IL-18 up-regulated the expression of the TNF receptors vascular cell adhesion molecule 1 ( VCAM-1 ) and intercellular adhesion molecule 1 ( ICAM-1 ) on monocytes
Salado et al., Journal of translational medicine 2011 (Inflammation...) : Second, resveratrol inhibited IL-18 dependent expression of VCAM-1 by tumor activated hepatic sinusoidal endothelium, preventing melanoma cell adhesion to the microvasculature
Deisher et al., Life Sci 1993 (Second Messenger Systems) : Surface protein expression of vascular cell adhesion molecule-1 , endothelial leukocyte adhesion molecule-1, or intercellular adhesion molecule-1, which is induced by tumor necrosis factor, interleukin-1 , and lipopolysaccharide, was not induced by pentoxyfilline, a phosphodiesterase inhibitor, nor by dibutyryl cyclic adenosine monophosphate
Miller et al., J Leukoc Biol 1998 : Utilizing neutralizing antibodies, we show that CD40L mediated tissue factor and thrombomodulin modulation, as well as E-selectin and VCAM-1 upregulation, is independent of tumor necrosis factor alpha, interleukin-1alpha , or interleukin-1beta production