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CD44 — MMP7

Pathways - manually collected, often from reviews:

• Reactome Reaction: CD44 → MMP7 (reaction) Ahmed et al., Carcinogenesis 2002*, Samanna et al., Exp Cell Res 2006*, Toole et al., Curr Opin Cell Biol 1990*
• Reactome Reaction: CD44 → MMP7 (direct_complex) Ahmed et al., Carcinogenesis 2002*, Samanna et al., Exp Cell Res 2006*, Toole et al., Curr Opin Cell Biol 1990*
• WikiPathways Wnt Signaling Pathway and Pluripotency: EP300 → Complex of 11 proteins (activation)
• WikiPathways Wnt Signaling Pathway and Pluripotency: ZBTB33 → Complex of 11 proteins (mim-inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MMP7 — CD44 (physical association, affinity chromatography technology) Yu et al., Genes Dev 2002*
• IRef Hprd Interaction: CD44 — MMP7 (in vivo) Yu et al., Genes Dev 2002*
• IRef Hprd Interaction: CD44 — MMP7 (in vitro) Yu et al., Genes Dev 2002*
• IRef Ophid Interaction: CD44 — MMP7 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Huh et al., J Cell Biochem 2007 : Both CD44v6 and its ectodomain cleavage products were detected from ED 5 to ED 14, and a broad-spectrum MMP inhibitor blocked ectodomain cleavage in cultured stromal cells
Campo et al., Biochim Biophys Acta 2009 : HA treatment produced different effects : low MW HA up-regulated CD44 expression, increased PKCdelta and PKCepsilon levels, and enhanced inflammation in untreated chondrocytes ; while in PMA treated cells it increased CD44, PKCdelta, PKCepsilon, NF-kB, TNF-alpha, IL-1beta, MMP-13 , and iNOS expression and enhanced the effects of PMA ; medium MW HA did not exert action ; high MW HA had no effect on untreated chondrocytes ; however, it reduced PKCdelta, PKCepsilon, NF-kB activation and inflammation in PMA stimulated cells