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IL4 — INS

Text-mined interactions from Literome

Chang et al., J Biol Chem 2000 (Burkitt Lymphoma...) : IL-4 also triggers phosphorylation of insulin receptor substrate (IRS) , leading to stimulation of cell growth
Mabley et al., Br J Pharmacol 2001 (Diabetes Mellitus, Experimental) : In vitro the cytokine combination ; interleukin-1beta , tumor necrosis factor-alpha and interferon-gamma inhibited glucose stimulated insulin secretion from isolated rat islets of Langerhans and decreased RIN-5F cell viability
Das et al., J Assoc Physicians India 2003 (Cardiomyopathies...) : Conversely, insulin suppresses production of MIF, TNF-alpha, IL-1, IL-6, and free radicals, enhances endothelial NO generation, and enhances the production of anti-inflammatory cytokines IL-4 , and IL-10, corrects stress hyperglycemia and improves myocardial function
Jeschke et al., Endocrinology 2004 (Endotoxemia) : In addition, insulin increased antiinflammatory cytokine expression in the liver ; serum levels of IL-2, IL-4 , and IL-10 ; and hepatic suppressor of cytokine signaling-3 mRNA expression
Rabinovitch et al., Diabetologia 1992 : The individual cytokines, interleukin 1 ( 1 U/ml ), tumour necrosis factor ( 10 ( 2 ) U/ml ), and interferon gamma ( 10 ( 2 ) U/ml ) inhibited insulin release but did not increase islet malondialdehyde levels
Fain et al., Metabolism 2005 : Insulin enhances vascular endothelial growth factor, interleukin-8 , and plasminogen activator inhibitor 1 but not interleukin-6 release by human adipocytes
Yelich et al., Pancreas 1992 : Effects of endotoxin and interleukin-1 on glucagon and insulin secretion from the perfused rat pancreas
Faresjö et al., Diabetes Metab Res Rev 2006 (Diabetes Mellitus, Type 1) : Fasting C-peptide levels at diagnosis correlated with insulin induced IFN-gamma ( R = 0.52 ; p = 0.05 ) and negatively with spontaneous IL-4 secretion ( R = -0.62 ; p < 0.05 )
Zawalich et al., Mol Cell Endocrinol 1991 : Influence of staurosporine, nitrendipine and monooleoylglycerol on interleukin-1 induced insulin secretion and phosphoinositide hydrolysis
Johannesen et al., Acta Endocrinol (Copenh) 1990 : During beta-cell stimulation with tolbutamide, interleukin 1 beta caused inhibition of insulin accumulation to 36 +/- 9 % of control
Sommese et al., Inflammopharmacology 1998 : Insulin regulates IL-1alpha, Ifn-y and IL-4 release from murine splenocytes stimulated with staphylococcal protein A, toxic shock syndrome toxin-1 and streptococcal lysin S
Shimizu et al., J Endocrinol Invest 1991 : Involvement of interleukin-1 in the inhibition of in vivo insulin release : possible role of adrenal glands
Uehara et al., Eur J Pharmacol 1991 (Hyperinsulinism) : With the aim of studying the mechanism by which peripherally injected interleukin-1 increases the serum levels of insulin in conscious rats, the effects of indomethacin, a cyclooxygenase inhibitor, on interleukin-1 induced hyperinsulinemia were examined using male Wistar rats implanted with intra-atrial cannulas ... It was also found that this insulin response to interleukin-1 was dose related ... Pretreatment with indomethacin ( 3 mg/kg body weight ), however, completely blocked the interleukin-1 induced stimulation of insulin secretion
Chen et al., Nat Med 2012 (Helminthiasis, Animal...) : We found that IL-17 initially contributed to inflammation and lung damage, whereas subsequent IL-4 receptor (IL-4R) signaling reduced elevations in IL-17 mRNA levels, enhanced the expression of insulin-like growth factor 1 (IGF-1) and IL-10 and stimulated the development of M2 macrophages, all of which contributed to the rapid resolution of tissue damage
Parazzoli et al., J Biol Chem 2012 : Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1ß induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets
Helqvist et al., Acta Endocrinol (Copenh) 1989 : Treatment with 10 mumol/l of verapamil ( a potent blocker of the voltage dependent calcium channel ) tended to suppress the inhibitory effect of interleukin 1 on insulin release from rat islets, suggesting protection against cytotoxicity
Hansen et al., Biomed Biochim Acta 1988 : Effect of interleukin-1 on the biosynthesis of proinsulin and insulin in isolated rat pancreatic islets
Sandler et al., Endocrinology 1987 : Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets
Rabinovitch et al., Diabetologia 1994 : The individual cytokines, interleukin 1 ( 10 U/ml ), tumour recrosis factor ( 10 ( 3 ) U/ml ) and interferon gamma ( 10 ( 3 ) U/ml ) inhibited insulin release from rat islets, but did not cause DNA fragmentation or destroy islet cells ; by contrast, combination of the three cytokines induced DNA fragmentation and islet-cell death
Galdiero et al., Eur Cytokine Netw 1995 : Effect of growth hormone, prolactin and insulin on the release of IL-1 alpha, IFN-gamma and IL-4 by staphylococcal enterotoxin A-stimulated splenocytes