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APC — TCF25

Text-mined interactions from Literome

Mariadason et al., Cancer Res 2001 : The down-regulation of beta-catenin-TCF signaling was independent of APC , which we characterized as having a nonsense mutation in codon 1367 in Caco-2 cells, but was associated with a decrease in TCF-4 protein levels
Faux et al., J Cell Sci 2004 (Colonic Neoplasms) : The ectopically expressed APC is functional, and results in the translocation of beta-catenin from the nucleus and cytoplasm to the cell periphery, and reduces beta-catenin/Tcf/LEF transcriptional signalling
Xing et al., Mol Cell 2004 : Our biochemical studies show that phosphorylation of the APC 20 aa repeats increases the affinity of the repeats for beta-catenin by 300- to 500-fold and the phosphorylated 20 aa repeats prevent beta-catenin binding to Tcf
Sarkar et al., Int Immunopharmacol 2008 (Edema) : Since nuclear factor-kappaB (NF-kappaB) appears to play a central role in transcriptional regulation of these proteins, we investigated the effects of APC on this transcription factor
Huang et al., Biochem Biophys Res Commun 2009 : Constitutive activation of the transcription factor TCF4 activity by mutated APC or beta-catenin contributes to cell neoplastic transformation