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PDGFB — RASA1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB)
→
RasGAP (RASA1)
(modification, collaborate)
Ekman et al., Oncogene 1999, Kaplan et al., Cell 1990*, Kazlauskas et al., Science 1990*, Molloy et al., Nature 1989*, Cooper et al., Mol Cell Biol 1993
Evidence: physical interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB)
→
PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB)
(modification, collaborate)
Ekman et al., Oncogene 1999, Kaplan et al., Cell 1990*, Kazlauskas et al., Science 1990*, Molloy et al., Nature 1989*, Cooper et al., Mol Cell Biol 1993
Evidence: physical interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
RasGAP (RASA1)
→
PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB)
(modification, collaborate)
Ekman et al., Oncogene 1999, Kaplan et al., Cell 1990*, Kazlauskas et al., Science 1990*, Molloy et al., Nature 1989*, Cooper et al., Mol Cell Biol 1993
Evidence: physical interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB)
→
PDGF-BB/PDGFRB (dimer)/RasGAP/Src Family Kinases complex (PDGFRB-RASA1-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-PDGFB)
(modification, collaborate)
Schlesinger et al., Biochem J 1999
Evidence: physical interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB)
→
Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
(modification, collaborate)
Schlesinger et al., Biochem J 1999
Evidence: physical interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP/Src Family Kinases complex (PDGFRB-RASA1-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-PDGFB)
→
Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
(modification, collaborate)
Schlesinger et al., Biochem J 1999
Evidence: physical interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB)
→
RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Ekman et al., Oncogene 1999, Ekman et al., Oncogene 2002, Gibbs et al., J Biol Chem 1990, Bazenet et al., Oncogene 1994
Evidence: assay
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB)
→
None
(modification, activates)
Ekman et al., Oncogene 1999, Ekman et al., Oncogene 2002, Gibbs et al., J Biol Chem 1990, Bazenet et al., Oncogene 1994
Evidence: assay
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB)
→
RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Ekman et al., Oncogene 1999, Ekman et al., Oncogene 2002, Gibbs et al., J Biol Chem 1990, Bazenet et al., Oncogene 1994
Evidence: assay
-
Reactome Reaction:
PDGFB
→
RASA1
(reaction)
Kashishian et al., EMBO J 1992*, Kazlauskas et al., Mol Cell Biol 1992*, Heldin et al., Biochim Biophys Acta 1998
-
Reactome Reaction:
PDGFB
→
RASA1
(indirect_complex)
Kashishian et al., EMBO J 1992*, Kazlauskas et al., Mol Cell Biol 1992*, Heldin et al., Biochim Biophys Acta 1998
Text-mined interactions from Literome
Molloy et al., Mol Cell Biol 1992
:
No significant GAP tyrosine phosphorylation was observed in unstimulated cultures, while
PDGF-BB induced rapid tyrosine phosphorylation of
GAP in all cell lines analyzed
Inui et al., J Biol Chem 1994
:
Following incubation with PDGF-AA or -BB, phospholipase C-gamma 1 ( PLC-gamma 1 ) and phosphatidylinositol 3-kinase were tyrosine phosphorylated ; however, the phosphorylation of
Ras-GTPase activating protein was
induced only by
PDGF-BB