Zito et al., J Biol Chem 2007
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We found that SHP-2 promoted AMPK activity under conditions of growth factor deprivation ( low energy ), suggesting that SHP-2 negatively regulates S6K1 via an AMPK dependent pathway
Mercan et al., Mol Cell Biol 2013
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Here we show that the protein tyrosine phosphatase SHP-2 is required for leucine induced activation of S6K1 in skeletal myoblasts