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Kiroytcheva et al., Kidney Int 1999
:
In oxygenated MTALs,
PKA mediated stimulation of Na+, K ( + )
-ATPase likely participates in the cAMP dependent stimulation of sodium reabsorption
Kurihara et al., Am J Physiol Cell Physiol 2000
:
These results show that Na ( + ) -K ( + )
-ATPase of rat parotid gland acinar cells is
regulated in vivo by membrane anchored
PKA via AKAP rather than by free cytosolic PKA
Vinciguerra et al., Mol Biol Cell 2003
:
The [ Na+ ] i-dependent increase in Na,
K-ATPase cell-surface expression was
prevented by
PKA inhibitors H89 and PKI
Pedrosa et al., Cell Physiol Biochem 2004
:
We have previously shown that the D1-mediated inhibition of
Na+-K+-ATPase activity in OK cells
involves the sequential activation of the AC-protein kinase A (
AC-PKA ) and the PLC-protein kinase C (PLC-PKC) pathways
Gomes et al., Eur J Pharmacol 2004
:
Dopamine D ( 1 ) -mediated inhibition of Na ( + ), K ( + )
-ATPase activity in opossum kidney ( OK ) cells
involves the sequential activation of the adenylyl
cyclase-protein kinase A (PKA) and the phospholipase C-protein kinase C ( PKC ) pathways
Mordasini et al., American journal of physiology. Renal physiology 2005
:
The effects of AVP on Na pump current and
Na-K-ATPase cell surface expression were
dependent on
PKA activity but independent of increased apical Na ( + ) entry ... Therefore, stimulation of
Na-K-ATPase cell surface expression by AVP is
dependent on
PKA but does not rely on alpha ( 1 ) -subunit phosphorylation on serine 943 in the collecting duct principal cells
Valverde et al., J Biol Chem 2005
:
When CaM kinase II was blocked by its specific inhibitor KN-93, the Ca2+-ATPase activity decreased to the levels measured in the absence of calmodulin ; the unusually high Ca2+ affinity dropped 2-fold ; and the
PKA mediated stimulation of
Ca2+-ATPase was no longer seen
Pastor-Soler et al., Am J Physiol Cell Physiol 2008
:
The
PKA inhibitor myristoylated-PKI ( mPKI, 10 microM )
inhibited the apical accumulation of
V-ATPase induced by 6-MB-cAMP ... We conclude that direct stimulation of
PKA activity by cAMP is necessary and
sufficient for the alkaline pH-induced accumulation of
V-ATPase in clear cell apical microvilli
Hallows et al., Am J Physiol Cell Physiol 2009
:
AMP activated protein kinase inhibits alkaline pH- and
PKA induced apical vacuolar
H+-ATPase accumulation in epididymal clear cells ... We have shown previously that
protein kinase A (PKA) , acting downstream of soluble adenylyl cyclase stimulation by alkaline luminal pH or HCO ( 3 ) ( - ),
induces V-ATPase apical membrane accumulation in clear cells ... Here we examined whether the metabolic sensor AMP activated protein kinase (AMPK) regulates this
PKA induced
V-ATPase apical membrane accumulation
Belleannée et al., Am J Physiol Cell Physiol 2010
:
The
PKA inhibitor myristoylated protein kinase inhibitor ( mPKI )
inhibited adenosine dependent
V-ATPase apical accumulation, indicating the participation of the P1 A2B receptor
Gong et al., American journal of physiology. Renal physiology 2010
:
Vacuolar
H+-ATPase apical accumulation in kidney intercalated cells is
regulated by
PKA and AMP activated protein kinase ... In developmentally related epididymal clear cells, we showed previously that
PKA , acting downstream of soluble adenylyl cyclase (sAC),
induces V-ATPase apical membrane accumulation ... Here, we examined the
regulation of
V-ATPase subcellular localization in intercalated cells by
PKA and AMPK in rat kidney tissue slices ex vivo
Lara et al., Arch Biochem Biophys 2010
:
Cholera toxin, an activator of Gs protein, mimicked it ; ( 2 ) in the presence of Ang II, Ang- ( 1-7 ) increased the PKA activity 10-fold ; ( 3 ) the peptide inhibitor of
PKA blocked the Ang- ( 1-7 ) effect on Ang II-stimulated
Na+-ATPase ; ( 4 ) Ang- ( 1-7 ) reverses the Ang II-stimulated PKC activity ; ( 5 ) cAMP mimicked the Ang- ( 1-7 ) effect on the Ang II-stimulated Na+-ATPase
Alzamora et al., J Biol Chem 2010
:
Finally, Ser-175 was necessary for
PKA stimulated apical accumulation of the
V-ATPase in a polarized rabbit cell line of collecting duct A-type intercalated cell characteristics ( Clone C )
Líbano-Soares et al., Arch Biochem Biophys 2011
:
The inhibitory effect of PGE2 on PT
Na+-ATPase activity
involves G-protein and the activation of
protein kinase A (PKA) because : ( 1 ) PGE2 increased [ 35S ] GTP?S binding ; ( 2 ) GDPßS abolished the inhibitory effect of PGE2 ; ( 3 ) PGE2 increased PKA activity ; ( 4 ) the inhibitory effect of PGE2 was abolished by PKA inhibitor peptide ... We observed that the
PKA mediated inhibitory effect of PGE2 on PT
Na+-ATPase activity requires previous activation of protein kinase C
Cheng et al., Am J Physiol 1997
:
PKA mediated phosphorylation and
inhibition of Na ( + ) -K ( + )
-ATPase in response to beta-adrenergic hormone