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LEF1 — PIAS4
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
PIAS4
—
LEF1
(physical association, affinity chromatography technology)
Sachdev et al., Genes Dev 2001*
-
IRef Biogrid Interaction:
PIAS4
—
LEF1
(direct interaction, pull down)
Sachdev et al., Genes Dev 2001*
-
IRef Biogrid Interaction:
PIAS4
—
LEF1
(direct interaction, two hybrid)
Sachdev et al., Genes Dev 2001*
-
IRef Hprd Interaction:
PIAS4
—
LEF1
(in vivo)
Sachdev et al., Genes Dev 2001*
-
IRef Hprd Interaction:
PIAS4
—
LEF1
(two hybrid)
Sachdev et al., Genes Dev 2001*
-
IRef Hprd Interaction:
PIAS4
—
LEF1
(in vitro)
Sachdev et al., Genes Dev 2001*
-
IRef Ophid Interaction:
PIAS4
—
LEF1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
PIAS4
—
LEF1
(aggregation, confirmational text mining)
Sachdev et al., Genes Dev 2001*
Text-mined interactions from Literome
Sachdev et al., Genes Dev 2001
:
PIASy , a nuclear matrix associated SUMO E3 ligase,
represses LEF1 activity by sequestration into nuclear bodies
Roth et al., J Immunol 2004
:
In particular,
PIASy has been shown to
inhibit the activation of gene expression by the IFN-responsive transcription factor STAT1 and the Wnt-responsive transcription factor
LEF1