◀ Back to P2RY12

P2RY12 — VASP

Text-mined interactions from Literome

Lee et al., Mol Cell Neurosci 2009 : PKA inhibitor effectively inhibited VASP phosphorylation and chemotaxis, indicating that P2Y12 mediated activation of PKA and subsequent VASP phosphorylation are involved in the regulation of microglia chemotaxis
Chang et al., Thromb Res 2010 : Flow cytometry was used to measure the effects of Ap ( 4 ) A in the presence or absence of ADP on : a ) P2Y(12) mediated decrease in intraplatelet phosphorylated vasodilator stimulated phosphoprotein ( VASP ), b ) P2Y(1) mediated increase in platelet cytosolic Ca ( 2+ ), and c ) P2X(1) mediated intraplatelet entry of extracellular Ca ( 2+ ) ... Ap ( 4 ) A inhibited 3 microM ADP induced : a ) platelet aggregation ( IC ( 50 ) 9.8+/-2.8 microM ), b ) P2Y(1) mediated shape change, c ) P2Y(1) mediated increase in platelet cytosolic Ca ( 2+ ) ( IC ( 50 ) 40.8+/-12.3 microM ), and d ) P2Y(12) mediated decrease in VASP phosphorylation ( IC ( 50 ) > 250 microM )
Judge et al., Thromb Haemost 2010 (Coronary Thrombosis) : A P2Y12 receptor blockade of 60-80 % resulted in strong inhibition of final PA response, P-selectin expression, microparticle formation and vasodilator stimulated phosphoprotein ( VASP )
Chang et al., Journal of thrombosis and haemostasis : JTH 2012 : We then measured the effects of these analogs on : ( i ) ADP induced platelet aggregation ; ( ii ) P2Y(1) mediated changes in cytosolic Ca ( 2+ ) ; ( iii ) P2Y(12) mediated changes in vasodilator stimulated phosphoprotein phosphorylation ; and ( iv ) P2X1 mediated entry of extracellular Ca ( 2+ )