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Text-mined interactions from Literome
Jerkic et al., FASEB J 2004
(Hypotension) :
Furthermore, overexpression or suppression of
endoglin in cultured cells
induced a marked increase or decrease in the protein levels of
eNOS , respectively ... Thus, our results in vivo and in vitro demonstrate a relationship between
endoglin and NO-dependent vasodilation
mediated by the regulation of
eNOS expression
Santibanez et al., J Cell Physiol 2007
:
Endoglin increases
eNOS expression by modulating Smad2 protein levels and Smad2 dependent TGF-beta signaling ... The
endoglin dependent induction of
eNOS occurs at the transcriptional level and is mediated by the type I TGF-beta receptor ALK5 and its downstream substrate Smad2
Nachtigal et al., Histol Histopathol 2009
(Hypercholesterolemia) :
It has been demonstrated that
endoglin can
affect TGF-beta signaling and
eNOS expression by affecting SMAD proteins in vitro