Gene interactions and pathways from curated databases and text-mining

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IL4 — IL4R

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Zhu et al., J Exp Med 2000 : It was found that IL-4 induced phosphorylation of Janus kinases 1 and 3, IL-4R alpha , signal transducer and activator of transcription 6, and insulin receptor substrate 2 was strikingly but transiently inhibited by TCR ligation both in conventional and TCR transgenic T cells
So et al., J Immunol 2000 : In human mononuclear cells and B cells isolated from tonsil or peripheral blood, IL-4 up-regulates IL-4R(alpha) expression at surface protein and mRNA levels, and the IL-4 induced IL-4R(alpha) is significantly down-regulated by both IFN-gamma and IFN-alpha to a similar extent
Frost et al., Bone 2001 : However, the antibodies did not affect the IL-4/-13 induced inhibition of [ ( 3 ) H ] -thymidine incorporation or the stimulation of alkaline phosphatase (ALP), suggesting that IL-4Ralpha does not mediate these effects of IL-4/-13 in hOBs
Barna et al., Cell Immunol 2001 : Immunoblotting demonstrated that EGF but not IL-4 increased astrocyte IL-4R alpha protein after 2 -- 4 days of exposure
Bonder et al., Growth Factors 2001 : Furthermore, IL-4 induced IL-4Ralpha chain phosphorylation more rapidly in MDMac and Mono Mac 6 cells than in monocytes and U937 cells
Hirst et al., Am J Respir Crit Care Med 2002 : Activation of IL-4Ralpha by IL-13 or IL-4 induced signal transducer and activation of transcription-6 ( STAT6 ), p42/ p44 ERK, p38, and to a lesser extent, SAPK/JNK mitogen activated protein kinase phosphorylation
Lutz et al., J Immunol 2002 : The IL-4R signaling for DC maturation requires the IL-4R alpha-chain and STAT6, but not Janus kinase 3, indicating that IL-4R type II signaling is preferentially responsible for these effects
Madden et al., J Immunol 2002 : Binding of IL-4 by either the type 1 or 2 IL-4R, or of IL-13 by the type 2 IL-4R , initiates Jak dependent tyrosine phosphorylation of the IL-4Ralpha-chain and the transcription factor, STAT6
Tykocinski et al., J Biol Chem 2005 : Naive T helper ( Th ) lymphocytes are induced to express the il4 ( interleukin-4 ) gene by simultaneous signaling through the T cell receptor and the interleukin (IL)-4 receptor
Mikhalkevich et al., J Immunol 2006 : The down-regulation of IL-4Ralpha diminished IL-4 signaling and the Th2 response and enhanced the Th1 response under suboptimal polarizing conditions
Akbar et al., Eur J Immunol 1991 : After activation, both subsets up-regulate their IL2 receptor (IL2R) and IL4R expression, yet IL4 substantially enhanced the proliferation of the CD4+CD45RA+ but not of the CD4+CD45R0+ T cell subset, while IL2 increased the proliferation of CD4+CD45R0+ but not of the CD4+CD45RA+ T cells
Andrews et al., J Allergy Clin Immunol 2006 : Furthermore, we found that IL-13Ralpha2 became associated with IL-4Ralpha in the presence of IL-4
Webb et al., J Immunol 2007 (Asthma...) : Because IL-4Ralpha is critical for IL-4 and IL-13 signaling, we also determined how variants of IL-4Ralpha influenced immune cell function
Liao et al., Nat Immunol 2008 : Although IL-4 induced IL-4Ralpha expression, T cell receptor induced IL-4Ralpha expression was normal in Il4 ( -/- ) cells but was much lower in Il2 ( -/- ) cells
Yamashita et al., FEBS Lett 2010 : We found that flavones inhibited IL-4 induced epsilon germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6, janus kinase 3, and IL-4Ralpha , whereas IL-4 signaling mediated through type II IL-4R was unaffected by flavones
Zuber et al., Eur J Immunol 1990 : Removal of IL 4 from cell cultures results in a two-to-fourfold increase of IL 4R levels 2 h later, suggesting an increase in IL 4R turnover
Kreitman et al., Cancer Res 1995 (Carcinoma) : IL4 ( 38-37 ) -PE38KDEL and IL4-PE38KDEL exhibited similar toxicity and pharmacokinetics in the mice, indicating that the improved antitumor activity of the circularly permuted IL4-toxin was due to its improved binding to the IL4R on the target cells
Mozo et al., J Allergy Clin Immunol 1998 : This immunosuppressor also diminished the IL-4 induced IL-4Ralpha expression on the surface of isolated T and B lymphocytes but, interestingly, without modifying mRNA levels that indicates that dexamethasone downregulated IL-4 dependent IL-4Ralpha expression by acting at a translational or posttranslational level