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IFNB1 — IL4
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Lou et al., Lab Invest 1999
(Multiple Sclerosis) :
Furthermore
IFN-beta did not modulate the expression of adhesion molecules on either stimulated leukocytes or activated HB-MVEC, but partially
reduced TNF and
interleukin-1 production from stimulated leukocytes during coculture with HB-MVEC
Pacocha et al., J Interferon Cytokine Res 2000
:
Finally, whereas
IFN-beta inhibited antigen-driven generation of IL-5, IL-12, IL-13, and IFN-gamma, IFN-beta
enhanced generation of both
IL-4 and IL-10
Yao et al., J Interferon Cytokine Res 2001
:
Regulation by
IFN-beta of inducible nitric oxide synthase and
interleukin-12/p40 in murine macrophages cultured in the presence of Chlamydia pneumoniae antigens
Dalod et al., J Exp Med 2002
:
Interferon alpha/beta and
interleukin 12
responses to viral infections : pathways regulating dendritic cell cytokine expression in vivo
Bahner et al., Neurosci Lett 2002
(Multiple Sclerosis, Chronic Progressive) :
Interferon-beta-1b increases serum
interleukin-12 p40 levels in primary progressive multiple sclerosis patients
Gobl et al., Scand J Immunol 1992
:
Recombinant
interleukin-4 ( rIL-4 )
caused a 65-70 % reduction of the
interferon-alpha (IFN-alpha) and -beta production induced by Sendai virus ( SV ) in human peripheral blood monocytes in vitro
Eriksen et al., J Biol Chem 2004
:
In addition,
IFN-alpha/beta inhibits
interleukin (IL)-4 signaling in B cells and monocytes, suggesting that IFN-alpha/beta ( like IFN-gamma ) is a Th1 cytokine
Sega et al., Clin Neurol Neurosurg 2004
(Multiple Sclerosis, Relapsing-Remitting) :
These two IFN have different influences on the pattern of cytokines in MS :
IFN-beta1a enhances the production of anti-inflammatory cytokines
IL-4 and IL-10 and IFN-beta1b decreases the production of the proinflammatory cytokine IFN-gamma
Marsh et al., J Neurosci 2009
(Infarction, Middle Cerebral Artery...) :
TLR4 can
induce both
IFNbeta and interferon stimulated genes through its adapter molecule
Toll/interleukin receptor domain containing adaptor inducing IFNbeta ( TRIF ) and the IRF3 transcription factor
Shirey et al., Mucosal Immunol 2010
(Lung Injury...) :
TLR4 signaling is required for peroxisome proliferator activated receptor gamma expression, a DNA binding protein that induces AA-M phi genes, whereas
IFN-beta regulates
IL-4 , IL-13, IL-4R alpha, and IL-10 expression in response to RSV
Sehgal et al., Proc Natl Acad Sci U S A 1987
:
The
enhancement of
IFN-beta 2 gene expression by diC8,
interleukin 1, or tumor necrosis factor was not prevented by H8, a preferential inhibitor of cAMP- and cGMP dependent protein kinases, but was blocked by H7, an inhibitor of protein kinase C as well as of cyclic nucleotide dependent protein kinases
Kohase et al., Mol Cell Biol 1987
:
Platelet derived growth factor and
interleukin-1 also
led to the increased expression of
IFN-beta 2
Cousens et al., Proc Natl Acad Sci U S A 1997
(Cytomegalovirus Infections...) :
Interferon-alpha/beta inhibition of
interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection
Eloranta et al., Scand J Immunol 1997
:
Priming the DC lines with tumour necrosis factor-alpha,
interleukin-10 (IL-10) or IL-4 did not
affect the
IFN-alpha/beta response induced by HSV ... Priming the DC lines with tumour necrosis factor-alpha, interleukin-10 (IL-10) or
IL-4 did not
affect the
IFN-alpha/beta response induced by HSV
Revel et al., Mult Scler 1995
(Breast Neoplasms...) :
In addition, study of MS patients treated with natural IFN-beta shows that
IFN-beta significantly
reduces serum levels of IFN-gamma while increasing
IL-4 , strongly suggesting that IFN-beta also controls the relative activation of TH1- and TH2-type T lymphocytes