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ICOS — IL12B

Text-mined interactions from Literome

Wassink et al., J Immunol 2004 : ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23 : increased ICOS expression enhances the effector function of both Th1 and Th2 cells ... ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23 : increased ICOS expression enhances the effector function of both Th1 and Th2 cells ... In this study, we show that ICOS expression on human Th cells is not increased by IL-4, but by IL-12 and by IL-23 instead ... As the ICOS enhancing potentials of IL-12 and IL-23 were maintained for several days after stimulation, both on Th1 and Th2 cells, we propose the concept that local regulation of ICOS expression on activated Th cells by IL-12 and/or IL-23 may provide a powerful means to amplify effector T cell responses in peripheral tissues, independently of the polarized state of the Th cells ... As the ICOS enhancing potentials of IL-12 and IL-23 were maintained for several days after stimulation, both on Th1 and Th2 cells, we propose the concept that local regulation of ICOS expression on activated Th cells by IL-12 and/or IL-23 may provide a powerful means to amplify effector T cell responses in peripheral tissues, independently of the polarized state of the Th cells
Ma et al., Immunol Cell Biol 2009 : However, only IL-12 induced sustained expressions of CXCR5 and ICOS on these activated naïve CD4 ( + ) T cells, and endowed them with the ability to provide increased help to B cells for their differentiation into immunoglobulin secreting cells