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Luciani et al., Endocrinology 2008
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Seladin-1 inhibits the activation of caspase-3 , a key modulator of apoptosis
Lu et al., J Mol Endocrinol 2012
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Confocal fluorescence microscopy revealed that the DHCR24 overexpressed cells were protected from apoptosis in response to oxidative stress, which was accompanied by a decrease in DHCR24 content on the ER and activation of caspase-3 , suggesting that the anti-apoptotic function of DHCR24 is associated with its cleavage by caspase