◀ Back to TP53
NFYC — TP53
Pathways - manually collected, often from reviews:
-
FastForward regulation:
NFYA, NFYB, NFYC
→
TP53
(transcriptional regulation, unknown)
Qin et al., Mol Endocrinol 2002*
Evidence: DNABINDING
-
NCI Pathway Database Direct p53 effectors:
p53 (tetramer)/NF-Y complex (TP53-NFYA-NFYC-NFYB)
→
NF-Y complex (NFYA-NFYB-NFYC)
(modification, collaborate)
Imbriano et al., Mol Cell Biol 2005*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Direct p53 effectors:
p53 (tetramer)/NF-Y complex (TP53-NFYA-NFYC-NFYB)
→
p53 (tetramer) complex (TP53)
(modification, collaborate)
Imbriano et al., Mol Cell Biol 2005*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Direct p53 effectors:
NF-Y complex (NFYA-NFYB-NFYC)
→
p53 (tetramer) complex (TP53)
(modification, collaborate)
Imbriano et al., Mol Cell Biol 2005*
Evidence: mutant phenotype, physical interaction
Text-mined interactions from Literome
Yun et al., J Biol Chem 1999
:
These results suggest that
p53 negatively regulates cdc2 transcription and that the
NF-Y transcription factor is
required for the p53 mediated regulation
Joshi et al., Mol Pharmacol 2003
:
The expression of mutant
p53 does not
affect the binding of
NF-Y
Yun et al., Cancer research and treatment : official journal of Korean Cancer Association 2006
:
p53 is essential to prevent immature escaping from cell cycle G2 checkpoint arrest through p21 mediated cdk2 inactivation, and this
leads to inhibition of cdk2 dependent
NF-Y phosphorylation and NF-Y dependent transcription of the cell cycle G2-regulatory genes, including cdc2 and cyclin B
Gurtner et al., Cancer Res 2010
:
Transcription factor
NF-Y induces apoptosis in cells expressing wild-type p53 through E2F1 upregulation and
p53 activation
Tue et al., Gene 2011
:
NF-Y transcriptionally
regulates the Drosophila
p53 gene
Park et al., Cardiovasc Res 2011
:
Anthracycline down-regulation of GATA4 is mediated by the inhibition of Gata4 gene transcription via a novel mechanism that involves the
p53 dependent inhibition of
CBF/NF-Y binding to the CCAAT box within the Gata4 promoter