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SERPINE1 — SMAD5

Text-mined interactions from Literome

Lee et al., Int J Cancer 2001 (Uterine Cervical Neoplasms) : Our findings demonstrate that ( i ) decrease of Smad4 mRNA expression is closely associated with defective TGF-beta response and lack of growth inhibition, ( ii ) activation of PAI-1 by TGF-beta may be Smad4 dependent and ( iii ) the Smad and the p38 cascades are triggered by TGF-beta independently of each other in human cervical cancer
Lee et al., American journal of physiology. Renal physiology 2004 (Diabetic Nephropathies) : This study examined whether glycated albumin induces PAI-1 transcription in human mesangial cells ( HMC ) through Smad binding sites in the PAI-1 promoter ... Thus progression of diabetic nephropathy may be promoted by PAI-1 upregulation mediated by the glycated albumin induced Smad/DNA interactions
Song et al., Kidney Int 2005 : This study examined whether oxidized low-density lipoprotein ( Ox-LDL ) activates PAI-1 transcription in human mesangial cells, mediated by increased Smad/DNA interactions
Hong et al., Translational research : the journal of laboratory and clinical medicine 2006 : ERK contributes to the effects of Smad signaling on oxidized LDL induced PAI-1 expression in human mesangial cells
He et al., J Biol Chem 2010 (MAP Kinase Signaling System) : Surprisingly, overexpression of Smad2 or Smad3 in HKC-8 cells blocked PAI-1 induction by TGF-beta1, whereas knockdown of them sensitized the cells to TGF-beta1 stimulation, suggesting that Smad signaling is not responsible for PAI-1 induction
Samarakoon et al., Cell Signal 2013 (Fibrosis) : Recent findings suggest a novel role for p53 in TGF-ß1 induced PAI-1 transcription that involves ROS generation and p53/SMAD interactions