UCSC Genome Browser Gene Interaction Graph

We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Gene interactions and pathways from curated databases and text-mining

◀ Back to PRKAA2

PRKAA2 — STAT3

Pathways - manually collected, often from reviews:

KEGG Adipocytokine signaling pathway: STAT3 → PRKAA1/PRKAA2/PRKAB1/PRKAB2/PRKAG1/PRKAG2/PRKAG3 (protein-protein, inhibition)

Text-mined interactions from Literome

Uotani et al., Biochem Biophys Res Commun 2006 : These findings suggest that the activation of JAK2, but not STAT3 , may play a critical role in leptin induced AMPK activation in Huh7 cells
Kim et al., Diabetologia 2012 (Insulin Resistance) : IL-6 induced STAT3 transactivation and SOCS3 production were significantly repressed by metformin, adenoviral constitutively active AMPK ( Ad-CA-AMPK ), and adenoviral SHP ( Ad-SHP ), but not in Shp knockdown, or with the adenoviral dominant negative form of AMPK ( Ad-DN-AMPK )