Gene interactions and pathways from curated databases and text-mining

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PI3 — VWF

Text-mined interactions from Literome

Yap et al., Blood 2002 : Results show that platelet adhesion and spreading on immobilized VWF results in a specific increase in the PI 3-kinase lipid product, PtdIns ( 3,4 ) P ( 2 )
Delaney et al., Arterioscler Thromb Vasc Biol 2012 : von Willebrand factor/GPIb-IX interaction sequentially activates the Src family kinase Lyn (SFK), phosphoinositide 3-kinase (PI3K) , and Akt, leading to activation of integrin a ( IIb ) ß ( 3 ) and integrin dependent stable platelet adhesion and aggregation