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CASP3 — NODAL

Text-mined interactions from Literome

Xu et al., J Clin Endocrinol Metab 2004 (Ovarian Neoplasms) : Transient transfection of Nodal and ALK7-ca significantly decreased X-linked inhibitor of apoptosis protein ( Xiap ) expression, activated both caspase-3 and caspase-9 , and increased apoptosis as determined by Hoechst nuclear staining and flow cytometry ... These findings demonstrate that Nodal induces apoptosis and inhibits proliferation via ALK7 and Smad2/3 and that the effect of Nodal-ALK7 on apoptosis may be mediated in part by the down-regulation of Xiap and activation of caspase-9 and caspase-3
Zhao et al., Am J Physiol Endocrinol Metab 2012 : Nodal treatment or overexpression of Nodal dose- or time-dependently increased active caspase-3 levels in INS-1 cells