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FAF1 — NFKB1

Text-mined interactions from Literome

Park et al., J Biol Chem 2004 : Fas associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB) activity by interfering with nuclear translocation of the RelA ( p65 ) subunit of NF-kappaB ... Here, we show that FAF1 is involved in negative regulation of NF-kappaB activation ... NF-kappaB activation induced by tumor necrosis factor (TNF)-alpha, interleukin-1beta, and lipopolysaccharide was also inhibited by FAF1 overexpression ... Moreover, FAF1 suppressed NF-kappaB activation induced by transducers of diverse NF-kappaB activating signals such as TNF receptor associated factor-2 and -6, MEKK1, and IkappaB kinase-beta as well as NF-kappaB p65, one of the end point molecules in the NF-kappaB activation pathway, suggesting that NF-kappaB p65 might be a target molecule upon which FAF1 acts ... Moreover, FAF1 suppressed NF-kappaB activation induced by transducers of diverse NF-kappaB activating signals such as TNF receptor associated factor-2 and -6, MEKK1, and IkappaB kinase-beta as well as NF-kappaB p65, one of the end point molecules in the NF-kappaB activation pathway, suggesting that NF-kappaB p65 might be a target molecule upon which FAF1 acts
Kinoshita et al., Int Immunol 2006 : In THP-1 cells, the stimulation of NF-kappaB up-regulated the level of endogenous FAF1