Gene interactions and pathways from curated databases and text-mining

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CD3E — CD4

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Portolés et al., Cell Immunol 1999 : Antibody induced CD3-CD4 coligation inhibits TCR/CD3 activation in the absence of costimulatory signals in normal mouse CD4 ( + ) T lymphocytes
Ulivieri et al., Eur J Immunol 1999 (Calcium Signaling) : While no calcium mobilization was measurable in cells defective for TCR/CD3 expression in response to CD4 engagement, the Ras/MAP kinase pathway could be partially activated
Sanzenbacher et al., J Immunol 1999 : SLP-76 binding to p56lck : a role for SLP-76 in CD4 induced desensitization of the TCR/CD3 signaling complex
Turka et al., J Immunol 1991 : Taken together, our data suggest a model of thymic development in which CD4 or CD8 may enhance TCR/CD3 signaling upon coligation by an MHC molecule
Zhong et al., PloS one 2009 : The ligation of TCR/CD3 on CD4 or CD8 T cells led to CD3 nanoscale co-clustering or interaction with CD4 or CD8 co-receptors forming 200-500 nm nano-domains or > 500 nm micro-domains
Zuñiga-Pflücker et al., J Exp Med 1989 : The TCR/CD3 upregulation occurs in the double positive population, and may result from CD4 signaling after mAb engagement, or may be a consequence of the blocked CD4-class II interactions
Thome et al., J Exp Med 1995 : Evidence has suggested that the association of CD4 with TCR/CD3/zeta requires the interaction of the protein tyrosine kinase p56lck with CD4