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Smith et al., Apoptosis 2003 (Cachexia) : At least part of the increase in caspase activity may be related to the increased proteasome proteolytic activity, since a caspase-3 inhibitor completely attenuated the PIF induced increase in 'chymotrypsin-like ' enzyme activity, the predominant proteolytic activity of the proteasome
Chen et al., In Vivo 2004 : We report that the extracts of apple and grape are more potent than onion, tomato and celery in : ( i ) inhibiting the proteasomal chymotrypsin-like activity in leukemia Jurkat T cell extract ; ( ii ) accumulating the polyubiquitinated proteins in intact Jurkat T cells ; ( iii ) inducing activation of caspase-3/-7 and cleavage of poly ( ADP-ribose ) polymerase in intact Jurkat T cells ; and ( iv ) inducing the appearance of spherical cells preferentially in prostate cancer PC-3 over the normal NIH 3T3 cell line