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PIK3CA — TSC2

Text-mined interactions from Literome

Sun et al., Proc Natl Acad Sci U S A 2008 : Consistent with a TSC-Rheb-PLD signaling cascade, AMPK and PI3K , both established regulators of TSC2 , appear to lie upstream of PLD as revealed by the effects of pharmacological inhibitors, and serum activation of PLD is also dependent on amino acid sufficiency
Habib et al., Genes & cancer 2011 : These novel data provide evidence that loss of TSC-2 , PTEN, and p53 as well as activation of PI 3-K and mTOR is associated with kidney cancer in the Eker rat, while sustained expression of TSC-2, PTEN, and p53 may prevent progression of kidney cancer in TSC patients