◀ Back to TNFRSF10B

CASP8 — TNFRSF10B

Pathways - manually collected, often from reviews:

• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: Caspase 3 (CASP3) → DR4/5/Caspase 8/Caspase 10/APO-2L complex (TNFRSF10B_TNFRSF10A-CASP8-CASP10-TNFSF10) (modification, collaborate)
  
• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: DR4/5/Caspase 8/Caspase 10 complex (TNFRSF10B_TNFRSF10A-CASP8-CASP10) → APO-2L (TNFSF10) (modification, collaborate)
• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: DR4/5/Caspase 8/Caspase 10 complex (TNFRSF10B_TNFRSF10A-CASP8-CASP10) → DR4/5/Caspase 8/Caspase 10/APO-2L complex (TNFRSF10B_TNFRSF10A-CASP8-CASP10-TNFSF10) (modification, collaborate)
  
• BioCarta induction of apoptosis through dr3 and dr4/5 death receptors: APO-2L (TNFSF10) → DR4/5/Caspase 8/Caspase 10/APO-2L complex (TNFRSF10B_TNFRSF10A-CASP8-CASP10-TNFSF10) (modification, collaborate)
  
• KEGG p53 signaling pathway: TNFRSF10B → CASP8 (protein-protein, indirect effect)
• NCI Pathway Database TRAIL signaling pathway: Caspase 8 (CASP8) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, collaborate)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Ganten et al., Cell Death Differ 2004, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) → Caspase 8 (tetramer) complex (CASP8) (modification, activates)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Kischkel et al., Immunity 2000, Ganten et al., Cell Death Differ 2004, Jin et al., Mol Cell Biol 2006, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: CASP8 → TNFRSF10B (indirect_complex) Sprick et al., Immunity 2000, Siegmund et al., J Biol Chem 2001, Boatright et al., Mol Cell 2003*, Sharp et al., J Biol Chem 2005*, Yerbes et al., Biochim Biophys Acta 2011*, Scaffidi et al., J Biol Chem 1999
• Reactome Reaction: CASP8 → TNFRSF10B (reaction) Sprick et al., Immunity 2000, Boatright et al., Mol Cell 2003*
• WikiPathways miRNA Regulation of DNA Damage Response: Complex of FAS-PIDD1-TNFRSF10B → CASP8 (activation) Strasser et al., Nat Rev Immunol 2005
• WikiPathways DNA Damage Response: Complex of FAS-PIDD1-TNFRSF10B → CASP8 (activation) Strasser et al., Nat Rev Immunol 2005

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TNFRSF10B — CASP8 (physical association, affinity chromatography technology) Guo et al., Blood 2005*
• IRef Biogrid Interaction: TNFRSF10B — CASP8 (physical association, affinity chromatography technology) Gonzalvez et al., Mol Cell 2012
• IRef Biogrid Interaction: TNFRSF10B — CASP8 (association, biochemical) Gajate et al., J Biol Chem 2005
• IRef Biogrid Interaction: TNFRSF10B — CASP8 (physical association, affinity chromatography technology) MacFarlane et al., J Biol Chem 1997
• IRef Biogrid Interaction: TNFRSF10B — CASP8 (physical association, affinity chromatography technology) Kim et al., J Biol Chem 2002*
• IRef Biogrid Interaction: TNFRSF10B — CASP8 (physical association, affinity chromatography technology) Kaunisto et al., Cell Death Differ 2009*
• IRef Biogrid Interaction: TNFRSF10B — CASP8 (direct interaction, enzymatic study) Kaunisto et al., Cell Death Differ 2009*
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Sprick et al., Immunity 2000
• IRef Hprd Interaction: Complex of 17 proteins MacFarlane et al., J Biol Chem 1997
• IRef Hprd Interaction: CASP8 — TNFRSF10B (in vivo) Söderström et al., J Immunol 2002*
• IRef Intact Interaction: Complex of TNFRSF10B-TNFSF10-FADD-CASP8 (association, pull down) Sprick et al., Immunity 2000
• IRef Intact Interaction: Complex of CASP8-SQSTM1-TNFRSF10B-TNFRSF10A (association, anti bait coimmunoprecipitation) Jin et al., Cell 2009
• IRef Intact Interaction: Complex of 21 proteins (association, anti bait coimmunoprecipitation) Jin et al., Cell 2009
• IRef Intact Interaction: Complex of CASP8-RIPK1-TNFRSF10A-TNFRSF10B-FADD-CFLAR (association, anti bait coimmunoprecipitation) Rébé et al., Blood 2007
• IRef Intact Interaction: Complex of FADD-CASP8-TNFRSF10B (association, anti bait coimmunoprecipitation) Pavet et al., Cancer Res 2010
• IRef Intact Interaction: Complex of 11 proteins (association, anti tag coimmunoprecipitation) Unterkircher et al., Clin Cancer Res 2011*
• IRef Intact Interaction: Complex of FADD-CASP8-TNFRSF10B-TNFRSF10A (association, anti bait coimmunoprecipitation) Pavet et al., Cancer Res 2010
• IRef Intact Interaction: Complex of 43 proteins (association, anti tag coimmunoprecipitation) Bangert et al., Oncogene 2012*
• IRef Intact Interaction: Complex of TNFRSF10B-TNFSF10-CFLAR-CASP8-FADD-CASP10 (association, pull down) Horova et al., FEBS J 2013
• IRef Intact Interaction: Complex of 16 proteins (association, anti tag coimmunoprecipitation) Jin et al., Cell 2009
• IRef Ophid Interaction: TNFRSF10B — CASP8 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: TNFRSF10B — CASP8 (aggregation, confirmational text mining) Söderström et al., J Immunol 2002*

Text-mined interactions from Literome