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E2F7 — SP1

Pathways - manually collected, often from reviews:

• FastForward regulation: SP1 → E2F7 (transcriptional regulation, unknown)
  Evidence: DNABINDING
• NCI Pathway Database E2F transcription factor network: E2F7-8 (E2F7) → SP1 (SP1) (transcription, inhibits) Di Stefano et al., EMBO J 2003, Christensen et al., Nucleic Acids Res 2005, Johnson et al., Genes Dev 1994, Hsiao et al., Genes Dev 1994
  Evidence: mutant phenotype, reporter gene, physical interaction

Text-mined interactions from Literome

Nicolás et al., Biochem J 2003 : Whereas overexpression of NF-Y or E2F had an additive effect on Sp1 overexpression, the activation of Sp1 transcription due to Sp1 was counteracted by Sp3 overexpression
Tapias et al., Cell cycle (Georgetown, Tex.) 2008 : Among the known Sp1 interacting proteins, E2F-DP1 , Cyclin D1, Stat3 and Rb activated the Sp1 promoter, whereas p53 and NF kappaB inhibited it
Hazar-Rethinam et al., J Invest Dermatol 2011 : Transient transfection of E2F1-E2F6 indicated that E2F mediated reduction of Sp1 transcription was not responsible for E2F mediated suppression of squamous differentiation ... However, we found that E2F4 and E2F7 , but not E2Fs 1, 2, 3, 5, or 6, could suppress the activation of the Sp1 promoter in differentiated keratinocytes (KCs)
Shao et al., Oncogene 1995 : Since Rb is a regulator of E2F and Sp1 mediated transcription, we have examined the effect of overexpression of cyclins on transcription mediated by E2F dependent adenovirus E2 promoter and by Sp1 in a cotransfection assay in 3T3 cells