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BACE1 — SP1

Text-mined interactions from Literome

Christensen et al., Mol Cell Biol 2004 (Alzheimer Disease) : Transcriptional regulation of BACE1 , the beta-amyloid precursor protein beta-secretase, by Sp1 ... These results suggest that BACE1 gene expression is tightly regulated at the transcriptional level and that the transcription factor Sp1 plays an important role in regulation of BACE1 to process APP generating Abeta in Alzheimer 's disease
Zhou et al., Ann N Y Acad Sci 2004 : BACE1 gene expression is tightly regulated at the transcriptional level and the transcription factor Sp1 plays an important role in regulation of BACE1 to process amyloid precursor protein generating amyloid beta protein
Sun et al., FASEB J 2005 (Alzheimer Disease...) : Though Sp1 can regulate both BACE1 and BACE2 genes, comparative sequence analysis and transcription factor prediction showed little similarity between the two promoters
Fang et al., Neuro Endocrinol Lett 2011 : SUMO negatively regulates the BACE expression and SP1 is involved in the process
Chu et al., Ann Neurol 2012 (Plaque, Amyloid) : Our findings demonstrate a novel pathway by which 12/15-LO increases the amyloidogenic processing of APP through a Sp1 mediated transcriptional control of BACE1 levels that could have implications for AD pathogenesis and therapy