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CASP8 — PTK2

Text-mined interactions from Literome

Jeong et al., Biochem J 2001 : Consistently, pp125FAK phosphorylation was increased, and both cleavage of pp125FAK and activation of caspase 3 on FN120 were partly blocked by peptide V
Rojas et al., Cell Immunol 2002 : Inhibitors of PTK ( AG-126 ), or JAK2 ( AG-490 ) inhibited TNF-alpha and NO production, caspase 1 activation and apoptosis, suggesting that M. tuberculosis-induction of these events depends on JAK2/STAT1-alpha activation
Levkau et al., J Exp Med 1998 : Therefore, caspase mediated cleavage of pp125FAK may be participating in the disassembly of the focal adhesion complex and actively interrupting survival signals from the extracellular matrix, thus propagating the cell death program