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ECM1 — MMP9

Text-mined interactions from Literome

Lupia et al., Diabetes 1999 (Diabetes Mellitus, Type 1...) : Because the extracellular matrix ( ECM ) accumulation in diabetic glomerulosclerosis may be partly due to decreased degradation, we examined the effect of excess IGF-1 on collagen turnover and the activity of metalloproteinases ( MMPs ) and tissue inhibitors of metalloproteinase ( TIMPs ) in diabetic and nondiabetic NOD-MC. Total collagen degradation was reduced by 58 +/- 18 % in diabetic NOD-MCs, which correlated with a constitutive decrease in MMP-2 activity and mRNA levels, and nearly undetectable MMP-9 activity and mRNA
Gottschalk et al., Adv Exp Med Biol 2000 (Endometriosis) : Matrix metalloproteinases ( MMP ) are involved in degradation of the extracellular matrix ( ECM )
Shibosawa et al., Am J Otol 2000 (Cholesteatoma, Middle Ear) : Matrix metalloprotease-9 (MMP-9) plays an important role in the degradation of extracellular matrix ( ECM ) ... These results suggest that the MMP-9 expressed in stromal cells may be involved in the disturbed cell-ECM interaction associated with the process of cholesteatoma formation
Uchio et al., Nephron 2000 (Disease Models, Animal...) : These results show that decreased MMP activities cause abnormal accumulation of ECM in ICGN mouse kidneys
Whiteside et al., Biol Reprod 2001 : These results provide important functional evidence that in vitro ECM degradation is regulated by embryo derived MMP-9 and ECM derived TIMP-3
Ghorpade et al., J Virol 2001 (AIDS Dementia Complex) : Regulation of MMP expression by these factors may contribute to neuropil ECM degradation and leukocyte migration during HAD
Ricke et al., Biol Reprod 2002 : Increased MMP activity may promote ECM degradation during luteolysis
Hornebeck et al., Semin Cancer Biol 2002 (Disease Progression...) : ECM preexisting modules or cryptic sites revealed by partial enzymatic hydrolysis positively or negatively regulate matrix metalloproteinase ( MMP ) expression and activation, further influencing matrix invasion by cancer cells
Marti et al., Transpl Immunol 2002 (Glomerulonephritis) : In vivo, a hydramate based MMP inhibitor attenuated excess mesangial cell proliferation and ECM accumulation in anti-Thy1.1 nephritis
Hornebeck et al., J Soc Biol 2003 : MMP mediated ECM degradation leads to the formation of peptides ( matricryptins, matrikins ) which, in turn, can modulate MMP expression
Wilson et al., Mol Cell Biochem 2003 (Arteriosclerosis...) : We conclude that reduced MMP levels could lead to increased ECM accumulation and thus contribute to early vascular lesion formation
Goicovich et al., Arthritis Rheum 2003 (Sjogren's Syndrome) : To determine the effect of matrix metalloproteinase ( MMP ) activity from the labial salivary glands ( LSGs ) of Sjögren 's syndrome ( SS ) patients on proteins of the extracellular matrix ( ECM ) that form the basal lamina and stroma, and to compare this effect with the structural integrity of acini and ducts as well as the functionality of the LSGs
Tao et al., Life Sci 2004 (Heart Rupture...) : Our data suggest that in mice, overexpression of MMP-2 and MMP-9 ( possibly expressed mainly by neutrophils and macrophages ) may lead to excessive ECM degradation in the early phase of MI, impairing infarct healing and aggravating early remodeling which in turn causes cardiac rupture
Khan et al., J Biol Chem 2004 (MAP Kinase Signaling System) : Moreover, ECM induced PGE ( 2 ) and MMP-9 expression by elicited COX-2 ( -/- ) macrophages is markedly reduced when compared with the response of either COX-2 ( +/- ) or COX-2 ( +/+ ) macrophages
Uchima et al., Pancreas 2004 (Adenocarcinoma...) : Tumor associated trypsinogen (TAT), urokinase-type plasminogen activator ( u-PA ), matrix metalloproteinase-2 (MMP-2), and MMP-9 each play a dominant role in the degradation of extracellular matrix ( ECM ) during the invasion process of pancreatic cancer
Sérandour et al., Hepatology 2005 : TNFalpha promoted an extracellular matrix ( ECM ) degradation that involved the matrix metalloproteinase MMP-9 induction through activation of NF-kappaB pathway
Linask et al., Dev Dyn 2005 : The experimental observations suggest that MMP activity regulates the coordination of early heart organogenesis by affecting ventral closure of the heart and gut tubes, asymmetric cell proliferation in the dorsal mesocardium to drive looping direction, and ECM degradation within the dorsal mesocardium allowing looping to proceed toward completion
Orlandi et al., Am J Pathol 2005 (Heart Neoplasms...) : Our results strongly suggest that MMP overexpression may contribute to an excessive degradation of tumor ECM and increase the risk of embolism in cardiac myxomas
Pavlovic et al., J Biol Chem 2006 (MAP Kinase Signaling System) : In addition, ECM induced MMP-9 expression was blocked in macrophages in which EP4 was silenced by small interfering RNA
Fujimoto et al., Exp Dermatol 2006 (Lipoid Proteinosis of Urbach and Wiethe) : We propose that ECM1 mediated reduction in MMP9 proteolytic activity may have relevance to pathogenesis of LP
Elliot et al., Invest Ophthalmol Vis Sci 2006 : Accordingly, loss of RPE MMP activity most likely leads to excessive accumulation of collagen and other ECM , a potential mechanism for formation of deposits
Chirco et al., Cancer Metastasis Rev 2006 (Disease Progression...) : Increasing evidence indicates a much more complex role for TIMPs during tumor progression and angiogenesis, in addition to their regulation of MMP mediated ECM degradation
Kumamoto et al., J Oral Pathol Med 2006 (Ameloblastoma...) : Expression of MT1-MMP, RECK and EMMPRIN in tooth germs and ameloblastic tumors suggests that these normal and neoplastic epithelial components control MMP dependent extracellular matrix ( ECM ) degradation during tooth development and tumor progression via epithelial-mesenchymal interactions
Cheng et al., FASEB J 2006 (Atrophy...) : It has been assumed that diminished matrix metalloproteinase ( MMP ) activity is responsible for the accumulation of the extracellular matrix ( ECM ) proteins and collagens that typify the fibrotic kidney
Takenaka et al., J Mol Cell Cardiol 2006 (Heart Failure...) : Local activation of Ang-II in hypertrophic LV triggers MMP mediated ECM degradation, namely LV remodeling, at least in part, through NADPH oxidase induced oxidative stress and the subsequent NFkappaB activation
Platt et al., J Heart Valve Dis 2006 : The down-regulation of cathepsin L activity correlates with an up-regulation of ECM synthesis ; MMP-2 and -9 activities increased with ECM synthesis under shear stress, showing that these proteinases may serve different roles in valvular remodeling ... The down-regulation of cathepsin L activity correlates with an up-regulation of ECM synthesis ; MMP-2 and -9 activities increased with ECM synthesis under shear stress, showing that these proteinases may serve different roles in valvular remodeling
Uchima et al., JOP : Journal of the pancreas 2007 (Adenocarcinoma...) : Tumor associated trypsinogen, urokinase-type plasminogen activator, matrix metalloprotease-2 (MMP-2), and MMP-9 each play a dominant role in the degradation of the extracellular matrix ( ECM ) during the invasion process of pancreatic cancer
Shi et al., Pharmacol Ther 2007 : Matrix metalloproteinases ( MMP ) play critical roles in ECM remodeling and/or regulation of cell-ECM interactions because of their ability to cleave protein components of the ECM
Itoh et al., J Endod 2009 : Matrix metalloproteinases ( MMPs ) such as interstitial collagenase ( MMP-1 ), gelatinase A ( MMP-2 ), gelatinase B ( MMP-9 ), and so on are products of inflammatory cells and, once activated, are intimately involved in the degradation of the ECM
Gill et al., Dev Growth Differ 2009 : We propose that increased MMP activity in the absence of TIMP3 enhances ECM proteolysis, upsetting proper formation of primitive alveolar septa during the saccular stage of alveologenesis
Buss et al., BMC neurology 2009 (Carotid Artery, Internal, Dissection...) : As matrix metalloproteinases ( MMP ) play a central role in the regulation of the ECM , an increased expression of these enzymes might lead to the endothelial damage in spontaneous cervical artery dissection ( sCAD )
Vanhoutte et al., J Mol Cell Cardiol 2010 (Heart Failure...) : Originally, TIMPs were thought to function exclusively as endogenous inhibitors of MMP activity, thereby fine tuning MMP mediated ECM degradation and numerous related processes
Hwang et al., Arch Oral Biol 2012 (Carcinoma, Squamous Cell...) : We provide evidence that HSC-3 OSCC has a tendency to adopt invadopodia for invasion and accompanying MMP dependent proteolytic ECM degradation and EGFR signalling is necessary for invadopodia formation and associated ECM degradation activity
Van Hul et al., Clin Exp Pharmacol Physiol 2012 (Body Weight...) : 1. Because the development of adipose tissue involves remodelling of the extracellular matrix ( ECM ) , which requires matrix metalloproteinase ( MMP ) activity, we examined whether MMP inhibitors may have the potential to affect adipose tissue mass in obese mice
Lu et al., Acta Trop 2013 : These results suggest that MMP-2 and MMP-9 induction from astroglia may contribute to extracellular matrix ( ECM ) degradation occurring in toxoplasmosis
Wang et al., J Obstet Gynaecol 2013 : We propose that MMP-2 and -9 may be involved in ECM degradation and placental barrier dysfunction, which facilitates T. gondii transmission to the fetus
Elmore et al., Ann Vasc Surg 1998 (Aortic Aneurysm, Abdominal) : This enhanced MMP-9 activity could then result in degradation of the ECM , leading to aneurysmal dilatation