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ANAPC2 — CCNB1

Pathways - manually collected, often from reviews:

• KEGG Cell cycle: Complex of 14 proteins → Complex of CCNB1-CCNB2-CCNB3-CDK1 (protein-protein, inhibition)
  
• KEGG Oocyte meiosis: Complex of 14 proteins → CCNB1 (protein-protein, inhibition)
• Reactome Reaction: ANAPC2 → CCNB1 (indirect_complex)
• Reactome Reaction: ANAPC2 → CCNB1 (reaction) Geley et al., J Cell Biol 2001, Golan et al., J Biol Chem 2002, Kraft et al., EMBO J 2003

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: ANAPC2 — CCNB1 (direct interaction, enzymatic study) Wu et al., Proc Natl Acad Sci U S A 2010
• IRef Biogrid Interaction: ANAPC2 — CCNB1 (direct interaction, enzymatic study) Lara-Gonzalez et al., J Cell Sci 2011
• IRef Biogrid Interaction: ANAPC2 — CCNB1 (physical association, affinity chromatography technology) Lara-Gonzalez et al., J Cell Sci 2011

Text-mined interactions from Literome

Guardavaccaro et al., Dev Cell 2003 (Infertility, Male) : Furthermore, cyclin A, cyclin B , and Emi1, an inhibitor of the anaphase promoting complex , are stabilized in mitotic beta-Trcp1 ( -/- ) MEFs
Liu et al., Theriogenology 2012 : Therefore, inactivation of maturation promoting factor is needed to finish the transition and complete both these divisions ; this is provided through anaphase promoting complex/cyclosome dependent degradation of cyclin B1