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MMP14 — SP1

Text-mined interactions from Literome

Yun et al., J Biol Chem 2002 : Transcription factor Sp1 phosphorylation induced by shear stress inhibits membrane type 1-matrix metalloproteinase expression in endothelium ... Thus, SS inhibits MT1-MMP expression despite Egr-1 up-regulation by inducing the serine phosphorylation of Sp1 , which in turn increases its binding affinity for its site on the MT1-MMP promoter, reducing the ability of Egr-1 to displace it
Sroka et al., Neoplasia (New York, N.Y.) 2007 (MAP Kinase Signaling System...) : Using human MT1-MMP promoter reporter plasmids and mobility shift assays, we show that Sp1 regulates MT1-MMP expression in DU-145, PC-3, and PC-3N cells and in PC3-N cells using chromatin immunoprecipitation analysis and silencing RNA ... These results indicate differential signaling control of Sp1 mediated transcriptional regulation of MT1-MMP in prostate cancer cell lines
Jutooru et al., Mol Pharmacol 2010 (Pancreatic Neoplasms) : CDDO-Me also induced reactive oxygen species ( ROS ) and decreased mitochondrial membrane potential ( MMP ) in Panc1 and L3.6pL cells, and cotreatment with antioxidants ( glutathione and dithiothreitol ) blocked the formation of ROS, reversed the loss of MMP , and inhibited down-regulation of Sp1 , Sp3, and Sp4