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TNF — TREM1

Text-mined interactions from Literome

Bouchon et al., J Immunol 2000 (Calcium Signaling...) : Engagement of TREM-1 triggers secretion of IL-8, monocyte chemotactic protein-1, and TNF-alpha and induces neutrophil degranulation
Bleharski et al., J Immunol 2003 (Inflammation) : Engagement of TREM-1 in combination with microbial ligands that activate Toll-like receptors also synergistically increased production of the proinflammatory cytokines TNF-alpha and GM-CSF, while inhibiting production of IL-10, an anti-inflammatory cytokine
Schenk et al., J Immunol 2005 : Intriguingly, in contrast to monocytes, intestinal macrophages fail to up-regulate TREM-1 in response to TNF
Murakami et al., J Immunol 2007 : Activation of TREM-1 expressed on PGE ( 2 ) -pretreated PBMC by an agonistic TREM-1 mAb significantly enhanced the production of IL-8 and TNF-alpha
Li et al., Dev Comp Immunol 2011 : Functionally, canine TREM-1 synergistically enhances LPS induced production of IL-8, TNF-a and a canine orthologue of CXCL1
Ormsby et al., Blood 2011 (Agammaglobulinemia...) : Importantly, TREM-1 induced production of the pro-inflammatory cytokines, TNF-a and IL-8, and up-regulation of activation/differentiation cell surface markers were impaired in Btk knockdown cells
Wang et al., Bosn J Basic Med Sci 2012 : Our finding that TREM-1 controls the production of IL-8 and TNF-a in U937 foam cells defines a potentially critical role of TREM-1 in the pathogenesis of atherosclerosis and implicates TREM-1 as a potential therapeutic target for the disease