Tamai et al., J Artif Organs 2007
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The alkaline phosphatase (ALP) activity of NHOst was also enhanced by NbTCP/HAp Fernandez et al., J Tissue Eng Regen Med 2011
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Evidence for this notion is based in several observations : ( a ) HAP-polymer increases proliferation of osteoblastic cells ; ( b ) HAP included in the blend increases the ALP expression in UMR106 cells ; ( c ) HAP-Blend increases the type-I collagen production in both cell lines, and d ) higher levels of the osteogenic transcription factor Runx-2 were detected when MC3T3E1 osteoblasts were induced to differentiate and mineralize on HAP-polymer scaffolds