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CYFIP1 — RAC2

Pathways - manually collected, often from reviews:

• KEGG Regulation of actin cytoskeleton: RAC1/RAC2/RAC3 → Complex of ABI2-CYFIP1-CYFIP2-NCKAP1-NCKAP1L (protein-protein, inhibition)
  

Text-mined interactions from Literome

Miki et al., Biochem Biophys Res Commun 2002 : Interestingly, the intramolecular interaction is interrupted by the binding of WAVE2 and full-length IRSp53 associates with Rac in the presence of WAVE2
Oikawa et al., Nat Cell Biol 2004 : Production of PtdIns ( 3,4,5 ) P ( 3 ) at the cell membrane by myristoylated phosphatidylinositol-3-OH kinase ( PI(3)K ) is sufficient to recruit WAVE2 in the presence of dominant negative Rac and latrunculin, demonstrating that PtdIns ( 3,4,5 ) P ( 3 ) alone is able to recruit WAVE2
Suetsugu et al., J Cell Biol 2006 : Purified WAVE2 and purified WAVE2 complex were activated by IRSp53 in a Rac dependent manner with PIP ( 3 ) -containing liposomes ... Therefore, IRSp53 optimizes the activity of the WAVE2 complex in the presence of activated Rac and PIP ( 3 )
Harmon et al., PLoS Pathog 2010 (Astrocytoma...) : Rac and the tyrosine kinase Abl then activate the Wave2 complex and promote Arp2/3 dependent actin polymerization