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Thomas et al., J Biol Chem 1999
:
We investigated the role of protein kinase A (PKA) in regulation of the human ether-a-go-go related gene (HERG) potassium channel activation ... We conclude that PKA regulates HERG channel activation, and direct phosphorylation of the HERG channel protein has a functional role that may be important in regulation of cardiac repolarization
Kagan et al., Novartis Found Symp 2005
(Long QT Syndrome) :
Elevations of cAMP as seen in beta-adrenergic stimulation can result in PKA dependent phosphorylation of hERG and direct binding of cAMP to the channel protein
Li et al., J Membr Biol 2008
:
Here, we report that the PKA-RII-specific AKAP inhibitory peptide AKAP-IS perturbs the distribution of PKA-RII and diminishes the PKA dependent phosphorylation of HERG protein
Sroubek et al., J Biol Chem 2011
:
A PKA inhibitor targeted to the ER surface ( termed p4PKIg ) completely abolished PKA mediated augmentation of HERG in HEK293 cells as well as rat neonatal cardiomyocytes ... Our results support a model where PKA dependent regulation of HERG synthesis occurs at the ER surface