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GNRH1 — PRKACG
Text-mined interactions from Literome
Vitalis et al., Proc Natl Acad Sci U S A 2000
:
In fact, pharmacological inhibition of
PKA activity
caused an increase in the basal secretion of
GnRH
Chiang et al., J Clin Endocrinol Metab 2000
:
Furthermore, our data suggest that the effects of hCG and
GnRH on ERalpha and ERbeta expression in hGLCs are
mediated in part by activation of
PKA and PKC signaling pathways, respectively
Ferris et al., Biol Reprod 2007
:
In LbetaT2 cells, cAMP stimulation of the Lhb promoter was eliminated by inhibition of protein kinase A (PKA) ;
GnRH1 stimulation was partially
suppressed by either
PKA or protein kinase C inhibitors ... Thus, cAMP stimulation of Lhb promoter activity, and enhancement of
GnRH1 stimulation, occurs in multiple physiological states independent of steroid status, via a
PKA dependent mechanism
Dhillon et al., Regul Pept 2009
:
Pharmacological inhibitors of the MAPK and
PKA signal transduction pathways
attenuated the NPY mediated increase in
GnRH transcription
Thompson et al., Mol Endocrinol 2013
:
GnRH stimulation of CREB phosphorylation ( pCREB ) in the gonadotrope derived LßT2 cell line was
attenuated by a
protein kinase A (PKA) inhibitor, H89
Lei et al., Mol Cell Endocrinol 1995
:
Treatment with the PKA inhibitor alone modestly decreased GnRH mRNA levels suggesting that
PKA signaling also
controls the basal expression of the
GnRH gene