UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to PIK3R2

ERBB2 — PIK3R2

Pathways - manually collected, often from reviews:

KEGG Focal adhesion: EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
KEGG Pathways in cancer: ERBB2 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
KEGG Pancreatic cancer: Complex of EGFR-ERBB2 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, indirect effect)
KEGG Prostate cancer: EGFR/ERBB2/FGFR1/FGFR2/IGF1R/INSRR/PDGFRA/PDGFRB → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
KEGG ErbB signaling pathway: Complex of ERBB2-ERBB4 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: PIK3R2 — ERBB2 (direct interaction, unspecified method) Jones et al., Nature 2006
IRef Biogrid Interaction: PIK3R2 — ERBB2 (direct interaction, enzymatic study) Gout et al., Biochem J 1992 *
IRef Biogrid Interaction: PIK3R2 — ERBB2 (direct interaction, pull down) Gout et al., Biochem J 1992 *
IRef Hprd Interaction: PIK3R2 — ERBB2 (in vivo) Gout et al., Biochem J 1992 *
IRef Intact Interaction: ERBB2 — PIK3R2 (direct interaction, protein array) Jones et al., Nature 2006
IRef Intact Interaction: ERBB2 — PIK3R2 (physical association, pull down) Schulze et al., Molecular systems biology 2005
MIPS Negatome - no physical interaction between proteins Interaction: ERBB2 — PIK3R2 (Absence of interaction, coimmunoprecipitation, MI:0110) Koutras et al., OncoTargets and therapy 2008 *
IRef Ophid Interaction: ERBB2 — PIK3R2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005