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HIF1A — MDM2

Pathways - manually collected, often from reviews:

• BioCarta hypoxia and p53 in the cardiovascular system: MDM2 → ubiquitin/p53/E2/HIF-1-alpha complex (TP53-UBE2A-HIF1A) (modification, activates)
  
• BioCarta hypoxia and p53 in the cardiovascular system: MDM2 → HIF-1-alpha (HIF1A) (modification, activates)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HIF1A — MDM2 (direct interaction, two hybrid) Lee et al., Carcinogenesis 2009*
• IRef Biogrid Interaction: HIF1A — MDM2 (physical association, affinity chromatography technology) Lee et al., Carcinogenesis 2009*
• IRef Biogrid Interaction: HIF1A — MDM2 (direct interaction, pull down) Lee et al., Carcinogenesis 2009*
• IRef Biogrid Interaction: HIF1A — MDM2 (direct interaction, pull down) Chen et al., J Biol Chem 2003*
• IRef Biogrid Interaction: HIF1A — MDM2 (physical association, affinity chromatography technology) Chen et al., J Biol Chem 2003*
• IRef Biogrid Interaction: HIF1A — MDM2 (direct interaction, enzymatic study) Ravi et al., Genes Dev 2000*
• IRef Hprd Interaction: HIF1A — MDM2 (in vivo) Ravi et al., Genes Dev 2000*, Chen et al., J Biol Chem 2003*
• IRef Hprd Interaction: HIF1A — MDM2 (in vitro) Ravi et al., Genes Dev 2000*, Chen et al., J Biol Chem 2003*
• IRef Innatedb Interaction: HIF1A — MDM2 (unknown, -) LaRusch et al., Cancer Res 2007*
• IRef Ophid Interaction: HIF1A — MDM2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Suzuki et al., Oncogene 2001 : Depletion of dephosphorylated HIF-1alpha also prevented hypoxia induced nuclear accumulation of HDM2 , a negative regulator of p53
Chen et al., J Biol Chem 2003 (Anoxia) : Interestingly, Mdm2 expression can significantly enhance the in vivo association between p53 and HIF-1 alpha, indicating that Mdm2 may act as a bridge and mediate the indirect interaction between HIF-1 alpha and p53 in cells
Bárdos et al., Mol Cell Biol 2004 : Transient expression of HDM2 led to increased expression of HIF-1alpha ... Finally, we showed that phosphorylation at Ser166 in HDM2 contributed in part to growth factor mediated induction of HIF-1alpha
Skinner et al., J Biol Chem 2004 (Ovarian Neoplasms) : HDM2 and p70S6K1 are two downstream targets of AKT that mediate growth factor induced VEGF transcriptional activation and HIF-1alpha expression
Lau et al., Biochem Biophys Res Commun 2006 (Carcinoma, Hepatocellular...) : In conclusion, YC-1 suppressed both protein synthesis and stability of HIF-1alpha in HCC cells, and its inhibitory effects on HIF-1alpha were dependent on Mdm2
LaRusch et al., Cancer Res 2007 : The vascular endothelial growth factor ( VEGF ) gene is a transcriptional target of HIF1alpha , and under normoxic or hypoxic conditions, Hdm2 increases HIF1alpha activity to induce VEGF production
Carroll et al., Cancer Res 2008 (Carcinoma, Renal Cell...) : We show in von Hippel-Lindau (VHL)-defective renal carcinoma cells that express constitutively high levels of HIF-1 alpha and HIF-2 alpha that down-regulation of HDM2 by siRNA leads to decreased levels of both HIF-1 alpha and HIF-2 alpha protein levels
Choy et al., J Cell Physiol 2010 (Cardiomegaly...) : In summary, we propose that p53 induced HIF1A degradation is not exclusively MDM2 mediated , but reversible by PKB/Akt phosphorylation