◀ Back to FOXO3

FASLG — FOXO3

Pathways - manually collected, often from reviews:

• NCI Pathway Database FoxO family signaling: FOXO3A (FOXO3) → FASLG (FASLG) (transcription, activates) Brunet et al., Cell 1999, Brunet et al., Science 2004
  Evidence: mutant phenotype, reporter gene
• NCI Pathway Database FoxO family signaling: FOXO3A/SIRT1 complex (FOXO3-SIRT1) → FASLG (FASLG) (transcription, inhibits) Brunet et al., Cell 1999, Brunet et al., Science 2004
  Evidence: mutant phenotype, reporter gene
• WikiPathways DNA Damage Response (only ATM dependent): FOXO3 → Complex of FASLG-BCL2L11-BCL6-BBC3 (activation)
  

Text-mined interactions from Literome

Suhara et al., Mol Cell Biol 2002 : Similarly, induction of FasL by the Akt regulated forkhead transcription factor FKHRL1 was dependent upon caspase and c-Jun activation ... Taken together, these results indicate that the sequential activation of caspase 3 and c-Jun participates in the induction of FasL under conditions of suppressed Akt signaling or FKHRL1 activation and that FasL participates in a positive-feedback loop to promote cell death under conditions of cellular stress
Behzad et al., Cytokine 2007 : Cytokine mediated FOXO3a phosphorylation suppresses FasL expression in hemopoietic cell lines : investigations of the role of Fas in apoptosis due to cytokine starvation