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EPHB2 — PLD2

Text-mined interactions from Literome

Hong et al., Biochem Biophys Res Commun 2001 : Enhancement of lysophosphatidic acid induced ERK phosphorylation by phospholipase D1 via the formation of phosphatidic acid
Banno et al., Neuroreport 2001 : Involvement of ERK and p38 MAP kinase in oxidative stress induced phospholipase D activation in PC12 cells ... To our knowledge, this study is the first demonstration that both ERK1/2 and p38 MAP kinase are involved in the PLD2 activation in PC12 cells exposed to H2O2
Lee et al., Neurosci Lett 2001 : Taken together, we suggest that PLD2 activity might play a negative role in ATP induced ERK phosphorylation and mitogenic signal possibly through phosphatases
Chen et al., J Biol Chem 2002 : In rat extensor digitorum longus (EDL) muscles, ( a ) AMPK activator, 5-aminoimidazole-4-carboxamide-1-beta-d-riboside ( AICAR ), activated PYK2, ERK and aPKCs ; ( b ) effects of AICAR on ERK and aPKCs were blocked by tyrosine kinase inhibitor, genistein, and MEK1 inhibitor, PD98059 ; and ( c ) effects of AICAR on aPKCs and 2-deoxyglucose ( 2-DOG ) uptake were inhibited by genistein, PD98059, and PLD-inhibitor , 1-butanol
Wang et al., Biochem J 2002 : The roles of PLD1 and PLD2 in ERK activation and IL-8 secretion activated by S1P were investigated by infecting cells with adenoviral constructs of wild-type and catalytically inactive mutants of PLD1 and PLD2
Andresen et al., Hypertension 2003 (MAP Kinase Signaling System) : In the present report, we confirm that phospholipase D-dependent generation of PA is required for Ang II-mediated phosphorylation of ERK in Wistar-Kyoto and spontaneously hypertensive rat preglomerular smooth muscle cells ( PGSMCs )
Yoon et al., Biochem Biophys Res Commun 2003 : Localization of Tie2 and phospholipase D in endothelial caveolae is involved in angiopoietin-1 induced MEK/ERK phosphorylation and migration in endothelial cells ... Ang1 induced MEK/ERK activation was abrogated when PLD was inhibited, suggesting that PLD mediates Ang1 induced MEK/ERK activation
Cho et al., Am J Physiol Heart Circ Physiol 2004 : Localization of VEGFR-2 and PLD2 in endothelial caveolae is involved in VEGF induced phosphorylation of MEK and ERK ... A PLD inhibitor, 1-butanol, almost completely suppressed VEGF induced ERK phosphorylation and cellular proliferation, whereas the negative control for 1-butanol, 3-butanol, did not produce significant changes
Jo et al., Life Sci 2004 (Translocation, Genetic) : Taken together, we found that WKYMVm stimulated FPRL1, and that this resulted in STAT3 serine phosphorylation via PLD mediated ERK activation, and that the serine phosphorylation of STAT3 blocked hydrogen peroxide induced STAT3 activity
Robin et al., Biol Reprod 2005 (Leiomyoma...) : Collectively, these data indicate that ET-1 is a potent mitogenic factor in ELT-3 cells via a signaling pathway involving a PLD dependent activation of ERK
Andresen et al., American journal of physiology. Renal physiology 2005 (Hypertension, Renal) : ANG II activation of phospholipase D ( PLD ) is required for ERK and NAD ( P ) H oxidase activation, both of which are involved in hypertension
Werry et al., J Neurochem 2005 (Calcium Signaling...) : Subsequent molecular characterization found that 5-HT stimulated ERK1/2 phosphorylation in this cellular background requires phospholipase D , protein kinase C, and activation of the Raf/MEK/ERK module, but is independent of both receptor- and non-receptor tyrosine kinases, phospholipase C, phosphoinositide 3-kinase, and endocytosis
Yoon et al., FEBS Lett 2005 : 8-Br-cAMP activated ERK1/2 , maximally at 5 min, and PD98059 ( MEK inhibitor : 50 microM ) and transfection of ES cells with dominant negative ( DN ) -MEK completely inhibited 8-Br-cAMP induced PLD activation, suggesting that ERK1/2 mediates the PLD activation ... Taken together, these results demonstrate a novel pathway in ES cells that 8-Br-cAMP activate PLD through PKA and ERK1/2 and this ERK/PLD activation by 8-Br-cAMP is mediated by Src and Ras, separately
Benitez-Rajal et al., Am J Physiol Gastrointest Liver Physiol 2006 : We report here, for the first time in HSC, that extracellular nucleotides stimulate PLD activity and a sustained activation of ERK
Oh et al., J Cell Biochem 2007 (Cell Transformation, Viral) : Interestingly, bFGF induced PLD activation and neurite outgrowth did not require ERK1/2 activated by Ras
Di Fulvio et al., Cell Signal 2008 : PLD2-Y179F caused an increase in phosphorylation of p42/p44 ERK and in the expression of G0/G1 phase transition markers ( p21 CIP, PCNA ), and these effects, too, were dependent on PI3K
Hamdi et al., Biochim Biophys Acta 2008 (MAP Kinase Signaling System) : Potential role of phospholipase D2 in increasing interleukin-2 production by T-lymphocytes through activation of mitogen activated protein kinases ERK1/ERK2 ... Analysis of the Ras-MAPK pathway upon phorbol myristate acetate ( PMA ) and ionomycin stimulation revealed that PLD2 promoted an early and sustained increase in ERK1/2 phosphorylation in both cell lines
Brandenburg et al., Neuroscience 2008 : Furthermore, the ERK1/2 phosphorylation by FPRL1 agonists was dependent on the PLD product phosphatidic acid ( PA )
Pergola et al., FASEB J 2011 : 5a-DHT ( 10 nM ) caused ERK phosphorylation and inhibition of phospholipase D ( PLD ) , as evaluated by Western blot and measurement of PLD activity via radioenzymatic diacylglyceride ( DAG ) and nonradioactive choline assays ... Our data indicate that ERK activation by androgens in monocytes represses PLD activity, resulting in impaired 5-LO product formation due to lack of activating DAGs
Pribic et al., Cell Signal 2012 : We investigated the role of PLD activity on paxillin regulation, Erk activation and formation of a paxillin-Erk and paxillin-FAK association