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BIRC5 — CASP3

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CASP3 — BIRC5 (direct interaction, pull down) Tamm et al., Cancer Res 1998*
• IRef Biogrid Interaction: CASP3 — BIRC5 (direct interaction, pull down) Shin et al., Biochemistry 2001*
• IRef Biogrid Interaction: CASP3 — BIRC5 (direct interaction, enzymatic study) Shin et al., Biochemistry 2001*
• IRef Hprd Interaction: BIRC5 — CASP3 (in vitro) Tamm et al., Cancer Res 1998*
• IRef Ophid Interaction: CASP3 — BIRC5 (aggregation, confirmational text mining) Tamm et al., Cancer Res 1998*
• IRef Ophid Interaction: CASP3 — BIRC5 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: CASP3 — BIRC5 (aggregation, confirmational text mining) Kasof et al., J Biol Chem 2001*

Text-mined interactions from Literome

Das et al., Cancer 2007 (Glioblastoma) : Other events in apoptosis included overexpression of Bax, down-regulation of Bcl-2 and some BIRC proteins, mitochondrial release of cytochrome c and Smac into the cytosol, and activation of calpain, caspase-9 , and caspase-3
Das et al., Brain Res 2008 (Brain Neoplasms...) : Besides, apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax : Bcl-2 ratio, mitochondrial release of cytochrome c and Smac, downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing ( BIRC ) molecules, an increase in intracellular free [Ca2+ ], and activation of calpain and caspase-3
Karmakar et al., Neuroscience 2009 (Body Weight...) : Combination of 4-HPR and GST increased Bax : Bcl-2 ratio, mitochondrial release of Smac, downregulation of baculovirus inhibitor-of-apoptosis repeat containing ( BIRC ) proteins including BIRC-2 and BIRC-3, and activation of caspase-3 and apoptosis inducing factor ( AIF )