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APC — CASP1
Text-mined interactions from Literome
Chen et al., Cancer Res 2003
(Colonic Neoplasms) :
Regulation of
caspase expression and apoptosis by
adenomatous polyposis coli
Kumar et al., J Cell Mol Med 2008
(Coronary Disease) :
APC significantly
reduced the rate of apoptosis ( 14.2 +/- 1.3 % ) and
caspase-3 activity
Guo et al., Eur J Neurosci 2009
(Anoxia...) :
In neurons and BECs,
3K3A-APC blocked
caspase-9 and -3 activation and induction of p53, and decreased the Bax/Bcl-2 pro-apoptotic ratio
Lu et al., Am J Physiol Heart Circ Physiol 2009
(Myocardial Reperfusion Injury) :
In addition to functional protection following I/R,
APC resulted in lower release of cytochrome c and
caspase-3 degradation
Gorbacheva et al., Neurochem Int 2013
:
To elucidate the NF-?B dependent and -independent mechanisms in the APC mediated cell survival, we analyzed in cortical and hippocampal neurons the
effects of helenalin, a specific inhibitor of NF-?B activity, and
APC on neuronal cell death and on the level of nuclear AIF, p53,
caspase-3 and the apoptotic index ( Bax/Bcl-2 ratio ) ... However,
APC , but not helenalin,
reduced the glutamate induced activation of
caspase-3