◀ Back to SKP2

RPL17 — SKP2

Text-mined interactions from Literome

Patsoukis et al., Science signaling 2012 (MAP Kinase Signaling System) : PD-1 suppressed SKP2 transcription by inhibiting phosphoinositide 3-kinase-Akt and Ras-mitogen activated and extracellular signal regulated kinase kinase ( MEK ) -extracellular signal regulated kinase ( ERK ) signaling
Patsoukis et al., Cell cycle (Georgetown, Tex.) 2012 : PD-1 did not alter the expression of G 1 phase cyclins or cyclin dependent kinases (Cdks) but, instead, suppressed the transcription of SKP2 , the substrate recognition component of the SCF ( Skp2 ) ubiquitin ligase that leads p27 ( kip1 ) to degradation and resulted in accumulation of p27 ( kip1 ) ... The suppressive effect of PD-1 on Skp2 expression was mediated by inhibition of both PI3K/Akt and Ras/MEK/Erk pathways and was only partially reversed by IL-2, which restored activation of MEK/Erk but not Akt