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ANAPC1 — SKP2

Pathways - manually collected, often from reviews:

• Reactome Reaction: ANAPC1 → SKP2 (indirect_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 32 proteins (association, anti tag coimmunoprecipitation)

Text-mined interactions from Literome

Liu et al., Mol Cell Biol 2007 : The Skp2 degradation is mediated by Cdh1-anaphase promoting complex (APC) , as shown by depletion of Cdh1 with small interfering RNA, and by reconstitution of ubiquitylation reactions in a purified system
Chen et al., Proc Natl Acad Sci U S A 2011 : Remarkably, down-regulation of Ufd1 enhances ubiquitination and destabilization of Skp2 mediated by the anaphase promoting complex or cyclosome bound to Cdh1 ( APC/C ( Cdh1 ) ), resulting in accumulation of the cyclin dependent kinase inhibitor p27 and a concomitant cell cycle delay during the G1 phase that enables more efficient clearance of misfolded proteins