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ABCC8 — SP1

Text-mined interactions from Literome

Hernández-Sánchez et al., J Biol Chem 1999 : The proximal promoter region contains multiple SP1 binding sites, and cotransfection experiments of the SUR1 promoter-luciferase vector with SP1 expression vector in Drosophila SL2 cells demonstrated a stimulatory effect of SP1 on SUR1 transcriptional activity
Woo et al., J Cereb Blood Flow Metab 2012 (Disease Models, Animal...) : Surprisingly, a series of luciferase reporter assays studying the Abcc8 promoter revealed that binding sites for specificity protein 1 (Sp1) , but not for HIF, were required for stimulation of Abcc8 transcription by HIF1a ... We conclude that sequential activation of two transcription factors, HIF and Sp1 , is required to stimulate transcription of Abcc8 following cerebral ischemia