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SLC22A3 — TCF12

Text-mined interactions from Literome

Peinado et al., EMBO J 2005 (Carcinoma) : The transcription factor Snail controls epithelial-mesenchymal transitions (EMT) by repressing E-cadherin expression and other epithelial genes
McKeithen et al., Prostate 2010 : Snail transcription factor induces epithelial-mesenchymal transition (EMT) via decreased cell adhesion associated molecules like E-cadherin, and increased mesenchymal markers like vimentin
Namba et al., Cell Death Differ 2010 (Pulmonary Fibrosis) : Smad interacting protein 1 ( a transcription factor regulating EMT ) and the Notch signaling pathway but not transforming growth factor-ß was shown to be involved in A771726 induced EMT-like phenotypes
Baritaki et al., Cell cycle (Georgetown, Tex.) 2010 (Neoplasms...) : EMT induction is mediated, in part, by the constitutive activation of the metastasis-inducer transcription factor , Snail and EMT can be inhibited by the metastasis-suppressor Raf-1 kinase inhibitor protein (RKIP) and E-cadherin
Neal et al., Cell Adh Migr 2011 (Prostatic Neoplasms) : Snail transcription factor induces epithelial-mesenchymal transition (EMT) in which the epithelial cells downregulate cell-cell adhesion genes such as E-Cadherin and upregulate mesenchymal genes such as vimentin, leading to increased invasion and migration
Tang et al., Int J Cancer 2012 (Pancreatic Neoplasms) : Furthermore, EGCG inhibited EMT by inhibiting the expression of Snail, Slug and ZEB1, and TCF/LEF transcriptional activity, which correlated with significantly reduced CSC 's migration and invasion, suggesting the blockade of signaling involved in early metastasis
Anastassiou et al., BMC cancer 2011 (Neoplasm Invasiveness...) : We found that human, but not mouse, cells express the signature and Slug is the only upregulated EMT inducing transcription factor
Shimoda et al., BMC cancer 2012 (Carcinoma, Adenoid Cystic...) : Surprisingly, shRNA silencing of the T-box transcription factor Brachyury ( also a differentiation marker ) resulted in downregulation of the EMT and stem cell markers
Zhu et al., Int J Oncol 2013 (Carcinoma, Transitional Cell...) : In conclusion that FOXQ1 may be a novel EMT inducing transcription factor through controlling the expression of E-cadherin and aggressiveness of cancer cells and targeting the transcription factor FOXQ1 could hence serve as a novel therapeutic strategy for cancer patients