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IL10 — PI3

Text-mined interactions from Literome

Barcova et al., Pflugers Arch 1999 : Thus HIV-1 gp41 induced IL-10 up-regulation in monocytes may not involve NF-kappaB, MAPK, or PI 3-kinase activation, but rather may operate through activation of adenylate cyclase and pertussis-toxin-sensitive Gi/Go protein to effect p70 ( S6 ) -kinase activation
Pahan et al., J Neurochem 2000 (Inflammation) : Both IL-10 and IL-13 caused rapid activation of phosphatidylinositol (PI) 3-kinase , and inhibition of that kinase activity by wortmannin and LY294002 potently blocked the inhibitory effect of IL-10 and IL-13 on proinflammatory cytokine mediated induction of ceramide production
Feito et al., Eur J Immunol 2003 (MAP Kinase Signaling System) : The association of phosphoinositide 3-kinase (PI-3K) to H4/ICOS was enhanced by H4/ICOS cross linking, and PI-3K inhibitors inhibited ERK and JNK activation and IL-4/IL-10 secretion, but not p38 MAP kinase or ZAP-70 activation
Bhattacharyya et al., Blood 2004 : Furthermore, IL-10 blocked inducible Akt phosphorylation, and inhibitors of phosphatidylinositol 3-kinase (PI3K) effectively suppressed the activation of Akt, IKK, and NF-kappaB
Saegusa et al., Mol Immunol 2007 : The aim of this study was to clarify the role of phosphatidylinositol 3-kinase (PI3K) on the production of interleukine-10 (IL-10) and IL-12 in mouse peritoneal macrophages stimulated with CpG-ODN
Sène et al., PLoS Pathog 2010 (Hepatitis C, Chronic...) : Using an endotoxin-free recombinant NS5A protein, we show that NS5A stimulation of monocytes through Toll-like Receptor 4 (TLR4) promotes p38- and PI3 kinase dependent IL-10 production, while inhibiting IL-12 production