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MAPK13 — ROCK1

Text-mined interactions from Literome

Pawlak et al., Mol Biol Cell 2002 (MAP Kinase Signaling System) : Investigating the mechanism underlying this phenotypic reversion, we found that the sustained MAPK signaling resulting from Ras-transformation down-regulated the expression of ROCKI and Rho-kinase, two-Rho effectors required for stress fiber formation, at the post-transcriptional level
Jia et al., Biol Cell 2006 : The localized activation of an autocrine HGF/c-Met loop regulates Rho/ROCK activation of p38 MAPK signalling to stimulate both membrane blebbing and pseudopod formation
Zeidan et al., Cardiovasc Res 2008 (Cardiomegaly) : Leptin induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK dependent p38 MAPK translocation to nuclei
Lingor et al., Brain 2008 : ROCK inhibition resulted in the activation of the intrinsic MAPK pathway, and the combination of CNTF and Y-27632 resulted in even more pronounced MAPK activation
Zohrabian et al., Anticancer Res 2009 (Glioblastoma...) : The cells were treated with Y-27632, a ROCK inhibitor, and U0126, an upstream MAPK kinase inhibitor ( MEK ), alone or in combination with one another
Moey et al., J Pharmacol Exp Ther 2011 (Cardiomegaly) : These results demonstrate a potent inhibitory effect of ginseng against leptin induced cardiac hypertrophy, an effect associated with prevention of p115RhoGEF-RhoA/ROCK dependent p38 MAPK activation