◀ Back to RAD21

CTNNB1 — RAD21

Text-mined interactions from Literome

Shekhar et al., Mol Cancer Res 2006 (Breast Neoplasms...) : Essential role of T-cell factor/beta-catenin in regulation of Rad6B : a potential mechanism for Rad6B overexpression in breast cancer cells ... Derepression and activation of Rad6B promoter in MCF10A cells require coexpression of beta-catenin and p300
Shekhar et al., Cancer Res 2008 (Breast Neoplasms) : Here, we show that forced Rad6B overexpression in MCF10A breast cells induces beta-catenin accumulation, which despite being ubiquitinated is stable and transcriptionally active ... A similar relationship between Rad6B, beta-catenin ubiquitination, and transcriptional activity was found in WS-15 and MDA-MB-231 breast cancer cells, and mouse mammary tumor virus-Wnt-1 mammary tumor derived cells, implicating Rad6B in physiologic regulation of beta-catenin stability and activity