UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to EGF

EGF — HSP90AA1

Pathways - manually collected, often from reviews:

NCI Pathway Database ErbB receptor signaling network: EGF (EGF) → HSP90 (dimer) complex (HSP90AA1) (modification, collaborate)
Citri et al., EMBO Rep 2004, Hazan et al., Cell Growth Differ 1990, Stern et al., EMBO J 1988 *, Qian et al., Proc Natl Acad Sci U S A 1994, Graus-Porta et al., EMBO J 1997
Evidence: assay, physical interaction
NCI Pathway Database ErbB receptor signaling network: EGF (EGF) → ErbB2/ErbB2/HSP90 (dimer) complex (ERBB2-HSP90AA1) (modification, collaborate)
Citri et al., EMBO Rep 2004, Hazan et al., Cell Growth Differ 1990, Stern et al., EMBO J 1988 *, Qian et al., Proc Natl Acad Sci U S A 1994, Graus-Porta et al., EMBO J 1997
Evidence: assay, physical interaction
NCI Pathway Database ErbB receptor signaling network: HSP90 (dimer) complex (HSP90AA1) → EGFR/ErbB2/EGF complex (EGFR-ERBB2-EGF) (modification, collaborate)
Citri et al., EMBO Rep 2004, Hazan et al., Cell Growth Differ 1990, Stern et al., EMBO J 1988 *, Qian et al., Proc Natl Acad Sci U S A 1994, Graus-Porta et al., EMBO J 1997
Evidence: assay, physical interaction
NCI Pathway Database ErbB receptor signaling network: ErbB2/ErbB2/HSP90 (dimer) complex (ERBB2-HSP90AA1) → EGFR/ErbB2/EGF complex (EGFR-ERBB2-EGF) (modification, collaborate)
Citri et al., EMBO Rep 2004, Hazan et al., Cell Growth Differ 1990, Stern et al., EMBO J 1988 *, Qian et al., Proc Natl Acad Sci U S A 1994, Graus-Porta et al., EMBO J 1997
Evidence: assay, physical interaction
Reactome Reaction: EGF → HSP90AA1 (reaction) Borg et al., Nat Cell Biol 2000, Xu et al., J Biol Chem 2001, Sordella et al., Science 2004, Citri et al., EMBO Rep 2004, Xu et al., Nature structural & molecular biology 2005, Greulich et al., PLoS Med 2005, Zhang et al., Cell 2006, Yang et al., Cancer Res 2006, Wahl et al., J Biol Chem 1990, Li et al., Cell Signal 2007, Lee et al., PLoS Med 2006, Yun et al., Cancer Cell 2007 *, Padrón et al., Cancer Res 2007, Wada et al., Cell 1990, Meisenhelder et al., Cell 1989, Karunagaran et al., EMBO J 1996, Pinkas-Kramarski et al., EMBO J 1996
Reactome Reaction: EGF → HSP90AA1 (indirect_complex)

Text-mined interactions from Literome

Yang et al., Cancer Res 2006 (Lung Neoplasms) : Association with HSP90 inhibits Cbl mediated down-regulation of mutant epidermal growth factor receptors
Adachi et al., Oncol Rep 2010 (Pancreatic Neoplasms) : HSP90 inhibitors induce desensitization of EGF receptor via p38 MAPK mediated phosphorylation at Ser1046/1047 in human pancreatic cancer cells