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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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CD40 — PTGS2

Text-mined interactions from Literome

Garlichs et al., Atherosclerosis 2002 (Inflammation) : Induction of cyclooxygenase-2 and enhanced release of prostaglandin E ( 2 ) and I ( 2 ) in human endothelial cells by engagement of CD40 ... The hypothesis was tested that CD40-CD154 interaction is involved in the induction of cyclooxygenase-2 and the release of prostanoids in human endothelial cells
Dongari-Bagtzoglou et al., Inflamm Res 2003 : CD40 ligation triggers COX-2 expression in endothelial cells : evidence that CD40 mediated IL-6 synthesis is COX-2 dependent ... To investigate whether CD40-CD154 interactions on HUVEC can trigger COX-2 synthesis as well as PGE2 and PGI2 secretion in vitro and explore whether the CD40 triggered prostanoids provide costimulatory signals for IL-6 secretion in this cell type ... These studies demonstrate that CD40 ligation upregulates HUVEC COX-2 expression and function
Inoue et al., J Immunol 2004 (MAP Kinase Signaling System) : Using specific inhibitors for extracellular signal related kinase ( ERK ) and p38 mitogen activated protein kinase ( MAPK ), we found that both kinase pathways are involved in CD40 induced COX-2 expression
Okuno et al., J Neurosci Res 2005 (Parkinson Disease) : We showed that both iNOS and COX-2 were up-regulated in microglia and astrocytes by CD 40 stimulation in association with a low dose of interferon-gamma (IFN-gamma) in vitro
Futagami et al., Prostaglandins Leukot Essent Fatty Acids 2008 (Stomach Neoplasms) : The aim of this study was to examine the effect of MCP-1/CCR2 and CD40-CD40L interaction on COX-2 and VEGF expression in endothelial cells ... CD40-CD40L interaction induced COX-2 production and subsequently, upregulated COX-2 production contributed to elevated VEGF and CCR2 levels in CD40L stimulated HUVECs
Cao et al., J Biol Chem 1998 (Graves Disease) : PGHS-2 is also induced by CD40 engagement in a time dependent manner, and this is mediated through increases in levels of steady-state mRNA ... CD40 cross linking enhances mitogen activated protein kinase activation, and interrupting this pathway attenuates the PGHS-2 induction